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Year Number of Results
2009 2
2010 2
2011 8
2012 4
2013 3
2014 3
2015 3
2016 2
2017 2
2019 1
2020 1
2021 6
2022 2
2023 1
2024 0

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35 results

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Page 1
mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells.
Bevers S, Kooijmans SAA, Van de Velde E, Evers MJW, Seghers S, Gitz-Francois JJJM, van Kronenburg NCH, Fens MHAM, Mastrobattista E, Hassler L, Sork H, Lehto T, Ahmed KE, El Andaloussi S, Fiedler K, Breckpot K, Maes M, Van Hoorick D, Bastogne T, Schiffelers RM, De Koker S. Bevers S, et al. Among authors: lehto t. Mol Ther. 2022 Sep 7;30(9):3078-3094. doi: 10.1016/j.ymthe.2022.07.007. Epub 2022 Jul 12. Mol Ther. 2022. PMID: 35821637 Free PMC article.
Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides.
Bost JP, Ojansivu M, Munson MJ, Wesén E, Gallud A, Gupta D, Gustafsson O, Saher O, Rädler J, Higgins SG, Lehto T, Holme MN, Dahlén A, Engkvist O, Strömstedt PE, Andersson S, Edvard Smith CI, Stevens MM, Esbjörner EK, Collén A, El Andaloussi S. Bost JP, et al. Among authors: lehto t. Commun Biol. 2022 Mar 1;5(1):185. doi: 10.1038/s42003-022-03132-2. Commun Biol. 2022. PMID: 35233031 Free PMC article.
Fine Tuning of Phosphorothioate Inclusion in 2'-O-Methyl Oligonucleotides Contributes to Specific Cell Targeting for Splice-Switching Modulation.
Aoki Y, Rocha CSJ, Lehto T, Miyatake S, Johansson H, Hashimoto Y, Nordin JZ, Mager I, Aoki M, Graham M, Sathyaprakash C, Roberts TC, Wood MJA, Behlke MA, Andaloussi SE. Aoki Y, et al. Among authors: lehto t. Front Physiol. 2021 Oct 13;12:689179. doi: 10.3389/fphys.2021.689179. eCollection 2021. Front Physiol. 2021. PMID: 34721051 Free PMC article.
Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo.
Bazaz S, Lehto T, Tops R, Gissberg O, Gupta D, Bestas B, Bost J, Wiklander OPB, Sork H, Zaghloul EM, Mamand DR, Hällbrink M, Sillard R, Saher O, Ezzat K, Smith CIE, Andaloussi SE, Lehto T. Bazaz S, et al. Among authors: lehto t. Biomedicines. 2021 Aug 19;9(8):1046. doi: 10.3390/biomedicines9081046. Biomedicines. 2021. PMID: 34440250 Free PMC article.
Efficient Peptide-Mediated In Vitro Delivery of Cas9 RNP.
Gustafsson O, Rädler J, Roudi S, Lehto T, Hällbrink M, Lehto T, Gupta D, Andaloussi SE, Nordin JZ. Gustafsson O, et al. Among authors: lehto t. Pharmaceutics. 2021 Jun 14;13(6):878. doi: 10.3390/pharmaceutics13060878. Pharmaceutics. 2021. PMID: 34198625 Free PMC article.
Delivery of oligonucleotide-based therapeutics: challenges and opportunities.
Hammond SM, Aartsma-Rus A, Alves S, Borgos SE, Buijsen RAM, Collin RWJ, Covello G, Denti MA, Desviat LR, Echevarría L, Foged C, Gaina G, Garanto A, Goyenvalle AT, Guzowska M, Holodnuka I, Jones DR, Krause S, Lehto T, Montolio M, Van Roon-Mom W, Arechavala-Gomeza V. Hammond SM, et al. Among authors: lehto t. EMBO Mol Med. 2021 Apr 9;13(4):e13243. doi: 10.15252/emmm.202013243. Epub 2021 Apr 6. EMBO Mol Med. 2021. PMID: 33821570 Free PMC article. Review.
35 results