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2020 2
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The Cytotoxic Effects of Cannabidiol and Cannabigerol on Glioblastoma Stem Cells May Mostly Involve GPR55 and TRPV1 Signalling.
Lah TT, Majc B, Novak M, Sušnik A, Breznik B, Porčnik A, Bošnjak R, Sadikov A, Malavolta M, Halilčević S, Mlakar J, Zomer R. Lah TT, et al. Cancers (Basel). 2022 Nov 30;14(23):5918. doi: 10.3390/cancers14235918. Cancers (Basel). 2022. PMID: 36497400 Free PMC article.
First, we found up-regulated CNR1, GPR55, and TRPV1 expression in glioma patient-derived tissue samples and cell lines compared with non-malignant brain samples. CNR1 and GPR55 did not correlate with glioma grade, whereas TRPV1 negatively correlated with grade and p …
First, we found up-regulated CNR1, GPR55, and TRPV1 expression in glioma patient-derived tissue samples and cell lines compared with …
TRIM28 Selective Nanobody Reduces Glioblastoma Stem Cell Invasion.
Porčnik A, Novak M, Breznik B, Majc B, Hrastar B, Šamec N, Zottel A, Jovčevska I, Vittori M, Rotter A, Komel R, Lah Turnšek T. Porčnik A, et al. Molecules. 2021 Aug 25;26(17):5141. doi: 10.3390/molecules26175141. Molecules. 2021. PMID: 34500575 Free PMC article.
Recently, transcription factor TRIM28 has been identified as a GB biomarker and, in this study, we have shown high expression of TRIM28 in GB and in low grade gliomas as well as higher expression in GSCs vs. differentiated GB cells, although in both cases not significant. …
Recently, transcription factor TRIM28 has been identified as a GB biomarker and, in this study, we have shown high expression of TRIM28 in G …
CCR5-Mediated Signaling Is Involved in Invasion of Glioblastoma Cells in Its Microenvironment.
Novak M, Koprivnikar Krajnc M, Hrastar B, Breznik B, Majc B, Mlinar M, Rotter A, Porčnik A, Mlakar J, Stare K, Pestell RG, Lah Turnšek T. Novak M, et al. Int J Mol Sci. 2020 Jun 12;21(12):4199. doi: 10.3390/ijms21124199. Int J Mol Sci. 2020. PMID: 32545571 Free PMC article.
CCL5 and CCR5 gene expression were significantly higher in a cohort of 38 glioblastoma samples, compared to low-grade glioma and non-cancerous tissues. The in vitro invasion of patients-derived primary glioblastoma cells and glioblastoma stem cells was dependent on CCL5-in …
CCL5 and CCR5 gene expression were significantly higher in a cohort of 38 glioblastoma samples, compared to low-grade glioma and non- …