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Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.
Bowman CE, Neinast MD, Jang C, Patel J, Blair MC, Mirek ET, Jonsson WO, Chu Q, Merlo L, Mandik-Nayak L, Anthony TG, Rabinowitz JD, Arany Z. Bowman CE, et al. bioRxiv [Preprint]. 2024 Mar 10:2024.03.05.582974. doi: 10.1101/2024.03.05.582974. bioRxiv. 2024. PMID: 38496495 Free PMC article. Preprint.
Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure.
Murashige D, Jung JW, Neinast MD, Levin MG, Chu Q, Lambert JP, Garbincius JF, Kim B, Hoshino A, Marti-Pamies I, McDaid KS, Shewale SV, Flam E, Yang S, Roberts E, Li L, Morley MP, Bedi KC Jr, Hyman MC, Frankel DS, Margulies KB, Assoian RK, Elrod JW, Jang C, Rabinowitz JD, Arany Z. Murashige D, et al. Cell Metab. 2022 Nov 1;34(11):1749-1764.e7. doi: 10.1016/j.cmet.2022.09.008. Epub 2022 Oct 11. Cell Metab. 2022. PMID: 36223763 Free PMC article.
Gut bacterial nutrient preferences quantified in vivo.
Zeng X, Xing X, Gupta M, Keber FC, Lopez JG, Lee YJ, Roichman A, Wang L, Neinast MD, Donia MS, Wühr M, Jang C, Rabinowitz JD. Zeng X, et al. Cell. 2022 Sep 1;185(18):3441-3456.e19. doi: 10.1016/j.cell.2022.07.020. Cell. 2022. PMID: 36055202 Free PMC article.
Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival.
Yang Y, Gomez M, Marsh T, Poillet-Perez L, Sawant A, Chen L, Park NR, Jackson SR, Hu Z, Alon N, Liu C, Debnath J, Guan JL, Davidson S, Verzi M, White E. Yang Y, et al. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2202016119. doi: 10.1073/pnas.2202016119. Epub 2022 May 10. Proc Natl Acad Sci U S A. 2022. PMID: 35537042 Free PMC article.