Szymkowski DE - Search Results

1

Inactivation of TNF signaling by rationally designed dominant-negative TNF variants.

Steed PM, Tansey MG, Zalevsky J, Zhukovsky EA, Desjarlais JR, Szymkowski DE, Abbott C, Carmichael D, Chan C, Cherry L, Cheung P, Chirino AJ, Chung HH, Doberstein SK, Eivazi A, Filikov AV, Gao SX, Hubert RS, Hwang M, Hyun L, Kashi S, Kim A, Kim E, Kung J, Martinez SP, Muchhal US, Nguyen DH, O'Brien C, O'Keefe D, Singer K, Vafa O, Vielmetter J, Yoder SC, Dahiyat BI. Steed PM, et al. Among authors: szymkowski de. Science. 2003 Sep 26;301(5641):1895-8. doi: 10.1126/science.1081297. Science. 2003. PMID: 14512626

2

Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection.

Zalevsky J, Secher T, Ezhevsky SA, Janot L, Steed PM, O'Brien C, Eivazi A, Kung J, Nguyen DH, Doberstein SK, Erard F, Ryffel B, Szymkowski DE. Zalevsky J, et al. Among authors: szymkowski de. J Immunol. 2007 Aug 1;179(3):1872-83. doi: 10.4049/jimmunol.179.3.1872. J Immunol. 2007. PMID: 17641054

3

The TNF superfamily in 2009: new pathways, new indications, and new drugs.

Tansey MG, Szymkowski DE. Tansey MG, et al. Among authors: szymkowski de. Drug Discov Today. 2009 Dec;14(23-24):1082-8. doi: 10.1016/j.drudis.2009.10.002. Epub 2009 Oct 28. Drug Discov Today. 2009. PMID: 19837186

4

Suppression of mast cell degranulation through a dual-targeting tandem IgE-IgG Fc domain biologic engineered to bind with high affinity to FcγRIIb.

Cemerski S, Chu SY, Moore GL, Muchhal US, Desjarlais JR, Szymkowski DE. Cemerski S, et al. Among authors: szymkowski de. Immunol Lett. 2012 Mar 30;143(1):34-43. doi: 10.1016/j.imlet.2012.01.008. Epub 2012 Jan 25. Immunol Lett. 2012. PMID: 22305932

5

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody.

Chu SY, Horton HM, Pong E, Leung IW, Chen H, Nguyen DH, Bautista C, Muchhal US, Bernett MJ, Moore GL, Szymkowski DE, Desjarlais JR. Chu SY, et al. Among authors: szymkowski de. J Allergy Clin Immunol. 2012 Apr;129(4):1102-15. doi: 10.1016/j.jaci.2011.11.029. Epub 2012 Jan 16. J Allergy Clin Immunol. 2012. PMID: 22257644

6

Immune suppression in cynomolgus monkeys by XPro9523: an improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn.

Bernett MJ, Chu SY, Leung I, Moore GL, Lee SH, Pong E, Chen H, Phung S, Muchhal US, Horton HM, Lazar GA, Desjarlais JR, Szymkowski DE. Bernett MJ, et al. Among authors: szymkowski de. MAbs. 2013 May-Jun;5(3):384-96. doi: 10.4161/mabs.23976. Epub 2013 Apr 2. MAbs. 2013. PMID: 23549103 Free PMC article.

7

Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcgammaRIIb with Fc-engineered antibodies.

Chu SY, Vostiar I, Karki S, Moore GL, Lazar GA, Pong E, Joyce PF, Szymkowski DE, Desjarlais JR. Chu SY, et al. Among authors: szymkowski de. Mol Immunol. 2008 Sep;45(15):3926-33. doi: 10.1016/j.molimm.2008.06.027. Epub 2008 Aug 8. Mol Immunol. 2008. PMID: 18691763

8

Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus.

Horton HM, Chu SY, Ortiz EC, Pong E, Cemerski S, Leung IW, Jacob N, Zalevsky J, Desjarlais JR, Stohl W, Szymkowski DE. Horton HM, et al. Among authors: szymkowski de. J Immunol. 2011 Apr 1;186(7):4223-33. doi: 10.4049/jimmunol.1003412. Epub 2011 Feb 28. J Immunol. 2011. PMID: 21357255

9

Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease.

McCoy MK, Martinez TN, Ruhn KA, Szymkowski DE, Smith CG, Botterman BR, Tansey KE, Tansey MG. McCoy MK, et al. Among authors: szymkowski de. J Neurosci. 2006 Sep 13;26(37):9365-75. doi: 10.1523/JNEUROSCI.1504-06.2006. J Neurosci. 2006. PMID: 16971520 Free PMC article.

10

Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia.

Karamita M, Barnum C, Möbius W, Tansey MG, Szymkowski DE, Lassmann H, Probert L. Karamita M, et al. Among authors: szymkowski de. JCI Insight. 2017 Apr 20;2(8):e87455. doi: 10.1172/jci.insight.87455. eCollection 2017 Apr 20. JCI Insight. 2017. PMID: 28422748 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

54 results

Search Page