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Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.
Lasica AM, Goulas T, Mizgalska D, Zhou X, de Diego I, Ksiazek M, Madej M, Guo Y, Guevara T, Nowak M, Potempa B, Goel A, Sztukowska M, Prabhakar AT, Bzowska M, Widziolek M, Thøgersen IB, Enghild JJ, Simonian M, Kulczyk AW, Nguyen KA, Potempa J, Gomis-Rüth FX. Lasica AM, et al. Among authors: sztukowska m. Sci Rep. 2016 Nov 24;6:37708. doi: 10.1038/srep37708. Sci Rep. 2016. PMID: 27883039 Free PMC article.
Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome.
Pomowski A, Usón I, Nowakowska Z, Veillard F, Sztukowska MN, Guevara T, Goulas T, Mizgalska D, Nowak M, Potempa B, Huntington JA, Potempa J, Gomis-Rüth FX. Pomowski A, et al. Among authors: sztukowska mn. J Biol Chem. 2017 Apr 7;292(14):5724-5735. doi: 10.1074/jbc.M117.776724. Epub 2017 Feb 14. J Biol Chem. 2017. PMID: 28196869 Free PMC article.
Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases.
Veillard F, Sztukowska M, Mizgalska D, Ksiazek M, Houston J, Potempa B, Enghild JJ, Thogersen IB, Gomis-Rüth FX, Nguyen KA, Potempa J. Veillard F, et al. Among authors: sztukowska m. Biochim Biophys Acta. 2013 Aug;1830(8):4218-28. doi: 10.1016/j.bbagen.2013.04.005. Epub 2013 Apr 10. Biochim Biophys Acta. 2013. PMID: 23583629 Free PMC article.
Noncanonical activation of β-catenin by Porphyromonas gingivalis.
Zhou Y, Sztukowska M, Wang Q, Inaba H, Potempa J, Scott DA, Wang H, Lamont RJ. Zhou Y, et al. Among authors: sztukowska m. Infect Immun. 2015 Aug;83(8):3195-203. doi: 10.1128/IAI.00302-15. Epub 2015 Jun 1. Infect Immun. 2015. PMID: 26034209 Free PMC article.
27 results