Szewczuk LM - Search Results

1

De novo discovery of serotonin N-acetyltransferase inhibitors.

Szewczuk LM, Saldanha SA, Ganguly S, Bowers EM, Javoroncov M, Karanam B, Culhane JC, Holbert MA, Klein DC, Abagyan R, Cole PA. Szewczuk LM, et al. J Med Chem. 2007 Nov 1;50(22):5330-8. doi: 10.1021/jm0706463. Epub 2007 Oct 9. J Med Chem. 2007. PMID: 17924613 Free PMC article.

2

A mechanism-based inactivator for histone demethylase LSD1.

Culhane JC, Szewczuk LM, Liu X, Da G, Marmorstein R, Cole PA. Culhane JC, et al. Among authors: szewczuk lm. J Am Chem Soc. 2006 Apr 12;128(14):4536-7. doi: 10.1021/ja0602748. J Am Chem Soc. 2006. PMID: 16594666

3

Mechanistic analysis of a suicide inactivator of histone demethylase LSD1.

Szewczuk LM, Culhane JC, Yang M, Majumdar A, Yu H, Cole PA. Szewczuk LM, et al. Biochemistry. 2007 Jun 12;46(23):6892-902. doi: 10.1021/bi700414b. Epub 2007 May 19. Biochemistry. 2007. PMID: 17511474 Free PMC article.

4

Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis.

Szewczuk LM, Tarrant MK, Sample V, Drury WJ 3rd, Zhang J, Cole PA. Szewczuk LM, et al. Biochemistry. 2008 Sep 30;47(39):10407-19. doi: 10.1021/bi801189d. Epub 2008 Sep 5. Biochemistry. 2008. PMID: 18771288 Free PMC article.

5

Protein phosphorylation by semisynthesis: from paper to practice.

Szewczuk LM, Tarrant MK, Cole PA. Szewczuk LM, et al. Methods Enzymol. 2009;462:1-24. doi: 10.1016/S0076-6879(09)62001-2. Methods Enzymol. 2009. PMID: 19632467 Free PMC article.

6

Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine.

Yang M, Culhane JC, Szewczuk LM, Jalili P, Ball HL, Machius M, Cole PA, Yu H. Yang M, et al. Among authors: szewczuk lm. Biochemistry. 2007 Jul 10;46(27):8058-65. doi: 10.1021/bi700664y. Epub 2007 Jun 15. Biochemistry. 2007. PMID: 17569509

7

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation.

Yang M, Culhane JC, Szewczuk LM, Gocke CB, Brautigam CA, Tomchick DR, Machius M, Cole PA, Yu H. Yang M, et al. Among authors: szewczuk lm. Nat Struct Mol Biol. 2007 Jun;14(6):535-9. doi: 10.1038/nsmb1255. Epub 2007 May 27. Nat Struct Mol Biol. 2007. PMID: 17529991

8

Modular Protein Ligation: A New Paradigm as a Reagent Platform for Pre-Clinical Drug Discovery.

Matico R, Szewczuk LM, Pietrak B, Chen S, Dul E, Bonnette WG, Meinhold DW, Quinque G, Totoritis R, Lewis T, Grimes M, Fornwald D, McCormick PM, Schaber M, Jiang Y, Bledsoe R, Holbert MA. Matico R, et al. Among authors: szewczuk lm. Sci Rep. 2019 Sep 11;9(1):13078. doi: 10.1038/s41598-019-49149-2. Sci Rep. 2019. PMID: 31511536 Free PMC article.

9

Development of a high-content imaging assay for screening compound aggregation.

Jiang Y, Hoffman A, Quinque G, Bonnette WG, Szewczuk LM, Holbert MA, Gross J. Jiang Y, et al. Among authors: szewczuk lm. Anal Biochem. 2018 Oct 15;559:30-33. doi: 10.1016/j.ab.2018.08.019. Epub 2018 Aug 21. Anal Biochem. 2018. PMID: 30142329

10

Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.

Zhang Z, Ghosh A, Connolly PJ, King P, Wilde T, Wang J, Dong Y, Li X, Liao D, Chen H, Tian G, Suarez J, Bonnette WG, Pande V, Diloreto KA, Shi Y, Patel S, Pietrak B, Szewczuk L, Sensenhauser C, Dallas S, Edwards JP, Bachman KE, Evans DC. Zhang Z, et al. J Med Chem. 2021 Aug 12;64(15):11570-11596. doi: 10.1021/acs.jmedchem.1c00890. Epub 2021 Jul 19. J Med Chem. 2021. PMID: 34279934

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