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Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.
Zhang Z, Ghosh A, Connolly PJ, King P, Wilde T, Wang J, Dong Y, Li X, Liao D, Chen H, Tian G, Suarez J, Bonnette WG, Pande V, Diloreto KA, Shi Y, Patel S, Pietrak B, Szewczuk L, Sensenhauser C, Dallas S, Edwards JP, Bachman KE, Evans DC. Zhang Z, et al. Among authors: szewczuk l. J Med Chem. 2021 Aug 12;64(15):11570-11596. doi: 10.1021/acs.jmedchem.1c00890. Epub 2021 Jul 19. J Med Chem. 2021. PMID: 34279934
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
Xu G, Liu Z, Wang X, Lu T, DesJarlais RL, Thieu T, Zhang J, Devine ZH, Du F, Li Q, Milligan CM, Shaffer P, Cedervall PE, Spurlino JC, Stratton CF, Pietrak B, Szewczuk LM, Wong V, Steele RA, Bruinzeel W, Chintala M, Silva J, Gaul MD, Macielag MJ, Nargund R. Xu G, et al. Among authors: szewczuk lm. J Med Chem. 2022 Aug 11;65(15):10419-10440. doi: 10.1021/acs.jmedchem.2c00442. Epub 2022 Jul 21. J Med Chem. 2022. PMID: 35862732
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor.
Wyatt RM, Fraser I, Welty N, Lord B, Wennerholm M, Sutton S, Ameriks MK, Dugovic C, Yun S, White A, Nguyen L, Koudriakova T, Tian G, Suarez J, Szewczuk L, Bonnette W, Ahn K, Ghosh B, Flores CM, Connolly PJ, Zhu B, Macielag MJ, Brandt MR, Chevalier K, Zhang SP, Lovenberg T, Bonaventure P. Wyatt RM, et al. Among authors: szewczuk l. J Pharmacol Exp Ther. 2020 Mar;372(3):339-353. doi: 10.1124/jpet.119.262139. Epub 2019 Dec 9. J Pharmacol Exp Ther. 2020. PMID: 31818916
Modular Protein Ligation: A New Paradigm as a Reagent Platform for Pre-Clinical Drug Discovery.
Matico R, Szewczuk LM, Pietrak B, Chen S, Dul E, Bonnette WG, Meinhold DW, Quinque G, Totoritis R, Lewis T, Grimes M, Fornwald D, McCormick PM, Schaber M, Jiang Y, Bledsoe R, Holbert MA. Matico R, et al. Among authors: szewczuk lm. Sci Rep. 2019 Sep 11;9(1):13078. doi: 10.1038/s41598-019-49149-2. Sci Rep. 2019. PMID: 31511536 Free PMC article.
Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors.
Lin H, Zeng J, Xie R, Schulz MJ, Tedesco R, Qu J, Erhard KF, Mack JF, Raha K, Rendina AR, Szewczuk LM, Kratz PM, Jurewicz AJ, Cecconie T, Martens S, McDevitt PJ, Martin JD, Chen SB, Jiang Y, Nickels L, Schwartz BJ, Smallwood A, Zhao B, Campobasso N, Qian Y, Briand J, Rominger CM, Oleykowski C, Hardwicke MA, Luengo JI. Lin H, et al. Among authors: szewczuk lm. ACS Med Chem Lett. 2015 Dec 28;7(3):217-22. doi: 10.1021/acsmedchemlett.5b00214. eCollection 2016 Mar 10. ACS Med Chem Lett. 2015. PMID: 26985301 Free PMC article.
De novo discovery of serotonin N-acetyltransferase inhibitors.
Szewczuk LM, Saldanha SA, Ganguly S, Bowers EM, Javoroncov M, Karanam B, Culhane JC, Holbert MA, Klein DC, Abagyan R, Cole PA. Szewczuk LM, et al. J Med Chem. 2007 Nov 1;50(22):5330-8. doi: 10.1021/jm0706463. Epub 2007 Oct 9. J Med Chem. 2007. PMID: 17924613 Free PMC article.
High-Throughput Assessment of Structural Continuity in Biologics.
Musetti C, Bean MF, Quinque GT, Kwiatkowski C, Szewczuk LM, Baldoni J, Zajac MA. Musetti C, et al. Among authors: szewczuk lm. Anal Chem. 2018 Feb 20;90(4):2970-2975. doi: 10.1021/acs.analchem.8b00180. Epub 2018 Feb 8. Anal Chem. 2018. PMID: 29369625 Free PMC article.
27 results