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4-Aryl-3-arylsulfonyl-quinolines as negative allosteric modulators of metabotropic GluR5 receptors: From HTS hit to development candidate.
Galambos J, Domány G, Nógrádi K, Wágner G, Keserű GM, Bobok A, Kolok S, Mikó-Bakk ML, Vastag M, Sághy K, Kóti J, Szakács Z, Béni Z, Gál K, Szombathelyi Z, Greiner I. Galambos J, et al. Among authors: szakacs z. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1249-52. doi: 10.1016/j.bmcl.2016.01.024. Epub 2016 Jan 11. Bioorg Med Chem Lett. 2016. PMID: 26774652
The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands.
Éliás O, Nógrádi K, Domány G, Szakács Z, Kóti J, Szántay C Jr, Tarcsay Á, Keserű GM, Gere A, Kiss B, Kurkó D, Kolok S, Némethy Z, Kapui Z, Hellinger É, Vastag M, Sághy K, Kedves R, Gyertyán I. Éliás O, et al. Among authors: szakacs z. Bioorg Med Chem Lett. 2016 Feb 1;26(3):914-920. doi: 10.1016/j.bmcl.2015.12.071. Epub 2015 Dec 21. Bioorg Med Chem Lett. 2016. PMID: 26748694
Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications.
Galambos J, Bielik A, Krasavin M, Orgován Z, Domány G, Nógrádi K, Wágner G, Balogh GT, Béni Z, Kóti J, Szakács Z, Bobok A, Kolok S, Mikó-Bakk ML, Vastag M, Sághy K, Laszy J, Halász AS, Balázs O, Gál K, Greiner I, Szombathelyi Z, Keserű GM. Galambos J, et al. Among authors: szakacs z. J Med Chem. 2017 Mar 23;60(6):2470-2484. doi: 10.1021/acs.jmedchem.6b01858. Epub 2017 Mar 1. J Med Chem. 2017. PMID: 28212015
Discovery of New Heterocyclic Ring Systems as Novel and Potent V1A Receptor Antagonists.
Baska F, Szántó G, Bozó É, Szakács Z, Dékány M, Szondiné Kordás K, Domány-Kovács K, Kurkó D, Hodoscsek B, Magdó I, Krámos B, Béni Z, Vastag M, Bata I. Baska F, et al. Among authors: szakacs z. ACS Chem Neurosci. 2020 Nov 4;11(21):3532-3540. doi: 10.1021/acschemneuro.0c00486. Epub 2020 Oct 21. ACS Chem Neurosci. 2020. PMID: 33084311
Synthesis and Characterization of New V1A Antagonist Compounds: The Separation of Four Atropisomeric Stereoisomers.
Szeleczky Z, Szakács Z, Bozó É, Baska F, Vukics K, Lévai S, Temesvári K, Vass E, Béni Z, Krámos B, Magdó I, Szántay C Jr, Kóti J, Domány-Kovács K, Greiner I, Bata I. Szeleczky Z, et al. Among authors: szakacs z. J Med Chem. 2021 Jul 22;64(14):10445-10468. doi: 10.1021/acs.jmedchem.1c00863. Epub 2021 Jul 13. J Med Chem. 2021. PMID: 34255509
[Microequilibrium of drug molecules].
Noszál B, Mazák K, Szakács Z. Noszál B, et al. Among authors: szakacs z. Acta Pharm Hung. 1999 Jun;69(3):108-14. Acta Pharm Hung. 1999. PMID: 10401153 Review. Hungarian.
172 results