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H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells.
Leszczynska KB, Freitas-Huhtamäki A, Jayaprakash C, Dzwigonska M, Vitorino FNL, Horth C, Wojnicki K, Gielniewski B, Szadkowska P, Kaza B, Nazarian J, Ciolkowski MK, Trubicka J, Grajkowska W, Garcia BA, Majewski J, Kaminska B, Mieczkowski J. Leszczynska KB, et al. Among authors: szadkowska p. Cell Rep. 2024 Feb 27;43(2):113707. doi: 10.1016/j.celrep.2024.113707. Epub 2024 Feb 1. Cell Rep. 2024. PMID: 38306270 Free PMC article.
Targeted sequencing of cancer-related genes reveals a recurrent TOP2A variant which affects DNA binding and coincides with global transcriptional changes in glioblastoma.
Gielniewski B, Poleszak K, Roura AJ, Szadkowska P, Jacek K, Krol SK, Guzik R, Wiechecka P, Maleszewska M, Kaza B, Marchel A, Czernicki T, Koziarski A, Zielinski G, Styk A, Kawecki M, Szczylik C, Czepko R, Banach M, Kaspera W, Szopa W, Bujko M, Czapski B, Zabek M, Iżycka-Świeszewska E, Kloc W, Nauman P, Cieslewicz J, Grajkowska W, Morosini N, Noushmehr H, Wojtas B, Kaminska B. Gielniewski B, et al. Among authors: szadkowska p. Int J Cancer. 2023 Sep 1;153(5):1003-1015. doi: 10.1002/ijc.34631. Epub 2023 Jun 20. Int J Cancer. 2023. PMID: 37338006
Exploring Novel Therapeutic Opportunities for Glioblastoma Using Patient-Derived Cell Cultures.
Ciechomska IA, Wojnicki K, Wojtas B, Szadkowska P, Poleszak K, Kaza B, Jaskula K, Dawidczyk W, Czepko R, Banach M, Czapski B, Nauman P, Kotulska K, Grajkowska W, Roszkowski M, Czernicki T, Marchel A, Kaminska B. Ciechomska IA, et al. Among authors: szadkowska p. Cancers (Basel). 2023 Mar 2;15(5):1562. doi: 10.3390/cancers15051562. Cancers (Basel). 2023. PMID: 36900355 Free PMC article.
Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications.
Roura AJ, Szadkowska P, Poleszak K, Dabrowski MJ, Ellert-Miklaszewska A, Wojnicki K, Ciechomska IA, Stepniak K, Kaminska B, Wojtas B. Roura AJ, et al. Among authors: szadkowska p. Clin Epigenetics. 2023 Feb 27;15(1):29. doi: 10.1186/s13148-023-01446-4. Clin Epigenetics. 2023. PMID: 36850002 Free PMC article.
Preservation of the Hypoxic Transcriptome in Glioblastoma Patient-Derived Cell Lines Maintained at Lowered Oxygen Tension.
Gozdz A, Wojtaś B, Szpak P, Szadkowska P, Czernicki T, Marchel A, Wójtowicz K, Kaspera W, Ladzinski P, Szopa W, Niedbala M, Nawrocki S, Kaminska B, Kalaszczynska I. Gozdz A, et al. Among authors: szadkowska p. Cancers (Basel). 2022 Oct 4;14(19):4852. doi: 10.3390/cancers14194852. Cancers (Basel). 2022. PMID: 36230775 Free PMC article.
Improvements in Quality Control and Library Preparation for Targeted Sequencing Allowed Detection of Potentially Pathogenic Alterations in Circulating Cell-Free DNA Derived from Plasma of Brain Tumor Patients.
Szadkowska P, Roura AJ, Wojtas B, Wojnicki K, Licholai S, Waller T, Gubala T, Zukowski K, Karpeta M, Wilkus K, Kaspera W, Nawrocki S, Kaminska B. Szadkowska P, et al. Cancers (Basel). 2022 Aug 12;14(16):3902. doi: 10.3390/cancers14163902. Cancers (Basel). 2022. PMID: 36010895 Free PMC article.