Effects of ATP depletion and phosphate analogues on P-glycoprotein conformation in live cells.
Goda K, Nagy H, Mechetner E, Cianfriglia M, Szabó G Jr.
Goda K, et al. Among authors: szabo g jr.
Eur J Biochem. 2002 Jun;269(11):2672-7. doi: 10.1046/j.1432-1033.2002.02929.x.
Eur J Biochem. 2002.
PMID: 12047375
Free article.
P-glycoprotein (Pgp), a membrane pump often responsible for the multidrug resistance of cancer cells, undergoes conformational changes in the presence of substrates/modulators, or upon ATP depletion, reflected by its enhanced reactivity with the UIC2 monoclonal antibody. When the …
P-glycoprotein (Pgp), a membrane pump often responsible for the multidrug resistance of cancer cells, undergoes conformational changes in th …