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Convergence of adenosine and GABA signaling for synapse stabilization during development.
Gomez-Castro F, Zappettini S, Pressey JC, Silva CG, Russeau M, Gervasi N, Figueiredo M, Montmasson C, Renner M, Canas PM, Gonçalves FQ, Alçada-Morais S, Szabó E, Rodrigues RJ, Agostinho P, Tomé AR, Caillol G, Thoumine O, Nicol X, Leterrier C, Lujan R, Tyagarajan SK, Cunha RA, Esclapez M, Bernard C, Lévi S. Gomez-Castro F, et al. Science. 2021 Nov 5;374(6568):eabk2055. doi: 10.1126/science.abk2055. Epub 2021 Nov 5. Science. 2021. PMID: 34735259
Adenosine receptor antagonists including caffeine alter fetal brain development in mice.
Silva CG, Métin C, Fazeli W, Machado NJ, Darmopil S, Launay PS, Ghestem A, Nesa MP, Bassot E, Szabó E, Baqi Y, Müller CE, Tomé AR, Ivanov A, Isbrandt D, Zilberter Y, Cunha RA, Esclapez M, Bernard C. Silva CG, et al. Sci Transl Med. 2013 Aug 7;5(197):197ra104. doi: 10.1126/scitranslmed.3006258. Sci Transl Med. 2013. PMID: 23926202 Free article.
Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage.
Boia R, Elvas F, Madeira MH, Aires ID, Rodrigues-Neves AC, Tralhão P, Szabó EC, Baqi Y, Müller CE, Tomé ÂR, Cunha RA, Ambrósio AF, Santiago AR. Boia R, et al. Among authors: szabo ec. Cell Death Dis. 2017 Oct 5;8(10):e3065. doi: 10.1038/cddis.2017.451. Cell Death Dis. 2017. PMID: 28981089 Free PMC article.