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Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy.
Dgachi Y, Ismaili L, Knez D, Benchekroun M, Martin H, Szałaj N, Wehle S, Bautista-Aguilera OM, Luzet V, Bonnet A, Malawska B, Gobec S, Chioua M, Decker M, Chabchoub F, Marco-Contelles J. Dgachi Y, et al. Among authors: szalaj n. ChemMedChem. 2016 Jun 20;11(12):1318-27. doi: 10.1002/cmdc.201500539. Epub 2016 Jan 25. ChemMedChem. 2016. PMID: 26804623
Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives.
Jończyk J, Lodarski K, Staszewski M, Godyń J, Zaręba P, Soukup O, Janockova J, Korabecny J, Sałat K, Malikowska-Racia N, Hebda M, Szałaj N, Filipek B, Walczyński K, Malawska B, Bajda M. Jończyk J, et al. Among authors: szalaj n. Bioorg Chem. 2019 Sep;90:103084. doi: 10.1016/j.bioorg.2019.103084. Epub 2019 Jun 26. Bioorg Chem. 2019. PMID: 31271942
Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease.
Szałaj N, Godyń J, Jończyk J, Pasieka A, Panek D, Wichur T, Więckowski K, Zaręba P, Bajda M, Pislar A, Malawska B, Sabate R, Więckowska A. Szałaj N, et al. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1944-1952. doi: 10.1080/14756366.2020.1835882. J Enzyme Inhib Med Chem. 2020. PMID: 33092411 Free PMC article.
Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters.
Pasieka A, Panek D, Jończyk J, Godyń J, Szałaj N, Latacz G, Tabor J, Mezeiova E, Chantegreil F, Dias J, Knez D, Lu J, Pi R, Korabecny J, Brazzolotto X, Gobec S, Höfner G, Wanner K, Więckowska A, Malawska B. Pasieka A, et al. Among authors: szalaj n. Eur J Med Chem. 2021 Jun 5;218:113397. doi: 10.1016/j.ejmech.2021.113397. Epub 2021 Mar 31. Eur J Med Chem. 2021. PMID: 33838585
Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer's Agents.
Pasieka A, Panek D, Szałaj N, Espargaró A, Więckowska A, Malawska B, Sabaté R, Bajda M. Pasieka A, et al. Among authors: szalaj n. ACS Chem Neurosci. 2021 Jun 2;12(11):2057-2068. doi: 10.1021/acschemneuro.1c00235. Epub 2021 May 21. ACS Chem Neurosci. 2021. PMID: 34019757 Free PMC article.
Serotonin 5-HT6 Receptor Ligands and Butyrylcholinesterase Inhibitors Displaying Antioxidant Activity-Design, Synthesis and Biological Evaluation of Multifunctional Agents against Alzheimer's Disease.
Więckowski K, Szałaj N, Gryzło B, Wichur T, Góral I, Sługocka E, Sniecikowska J, Latacz G, Siwek A, Godyń J, Bucki A, Kołaczkowski M, Więckowska A. Więckowski K, et al. Among authors: szalaj n. Int J Mol Sci. 2022 Aug 21;23(16):9443. doi: 10.3390/ijms23169443. Int J Mol Sci. 2022. PMID: 36012707 Free PMC article.
16 results