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Page 1
Lipodystrophy in methylmalonic acidemia associated with elevated FGF21 and abnormal methylmalonylation.
Manoli I, Sysol JR, Head PE, Epping MW, Gavrilova O, Crocker MK, Sloan JL, Koutsoukos SA, Wang C, Ktena YP, Mendelson S, Pass AR, Zerfas PM, Hoffmann V, Vernon HJ, Fletcher LA, Reynolds JC, Tsokos MG, Stratakis CA, Voss SD, Chen KY, Brown RJ, Hamosh A, Berry GT, Chen XS, Yanovski JA, Venditti CP. Manoli I, et al. Among authors: sysol jr. JCI Insight. 2024 Feb 22;9(4):e174097. doi: 10.1172/jci.insight.174097. JCI Insight. 2024. PMID: 38271099 Free PMC article.
Sphingosine Kinase 1 Deficiency in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension via YAP1 Signaling.
Chen J, Lockett A, Zhao S, Huang LS, Wang Y, Wu W, Tang M, Haider S, Velez Rendon D, Khan R, Liu B, Felesena N, Sysol JR, Valdez-Jasso D, Tang H, Bai Y, Natarajan V, Machado RF. Chen J, et al. Among authors: sysol jr. Int J Mol Sci. 2022 Nov 22;23(23):14516. doi: 10.3390/ijms232314516. Int J Mol Sci. 2022. PMID: 36498853 Free PMC article.
Cortactin loss protects against hemin-induced acute lung injury in sickle cell disease.
Jones NM, Sysol JR, Singla S, Smith P, Sandusky GE, Wang H, Natarajan V, Dudek SM, Machado RF. Jones NM, et al. Among authors: sysol jr. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 1;322(6):L890-L897. doi: 10.1152/ajplung.00274.2021. Epub 2022 May 3. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35503995 Free PMC article.
FGF21 underlies a hormetic response to metabolic stress in methylmalonic acidemia.
Manoli I, Sysol JR, Epping MW, Li L, Wang C, Sloan JL, Pass A, Gagné J, Ktena YP, Li L, Trivedi NS, Ouattara B, Zerfas PM, Hoffmann V, Abu-Asab M, Tsokos MG, Kleiner DE, Garone C, Cusmano-Ozog K, Enns GM, Vernon HJ, Andersson HC, Grunewald S, Elkahloun AG, Girard CL, Schnermann J, DiMauro S, Andres-Mateos E, Vandenberghe LH, Chandler RJ, Venditti CP. Manoli I, et al. Among authors: sysol jr. JCI Insight. 2018 Dec 6;3(23):e124351. doi: 10.1172/jci.insight.124351. JCI Insight. 2018. PMID: 30518688 Free PMC article.
Loss of lung WWOX expression causes neutrophilic inflammation.
Singla S, Chen J, Sethuraman S, Sysol JR, Gampa A, Zhao S, Machado RF. Singla S, et al. Among authors: sysol jr. Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L903-L911. doi: 10.1152/ajplung.00034.2017. Epub 2017 Mar 10. Am J Physiol Lung Cell Mol Physiol. 2017. PMID: 28283473 Free PMC article.
Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension.
Chen J, Sysol JR, Singla S, Zhao S, Yamamura A, Valdez-Jasso D, Abbasi T, Shioura KM, Sahni S, Reddy V, Sridhar A, Gao H, Torres J, Camp SM, Tang H, Ye SQ, Comhair S, Dweik R, Hassoun P, Yuan JX, Garcia JGN, Machado RF. Chen J, et al. Among authors: sysol jr. Circulation. 2017 Apr 18;135(16):1532-1546. doi: 10.1161/CIRCULATIONAHA.116.024557. Epub 2017 Feb 15. Circulation. 2017. PMID: 28202489 Free PMC article.
19 results