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A synthetic antibiotic class overcoming bacterial multidrug resistance.
Mitcheltree MJ, Pisipati A, Syroegin EA, Silvestre KJ, Klepacki D, Mason JD, Terwilliger DW, Testolin G, Pote AR, Wu KJY, Ladley RP, Chatman K, Mankin AS, Polikanov YS, Myers AG. Mitcheltree MJ, et al. Among authors: syroegin ea. Nature. 2021 Nov;599(7885):507-512. doi: 10.1038/s41586-021-04045-6. Epub 2021 Oct 27. Nature. 2021. PMID: 34707295 Free PMC article.
Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides.
Khabibullina NF, Tereshchenkov AG, Komarova ES, Syroegin EA, Shiriaev DI, Paleskava A, Kartsev VG, Bogdanov AA, Konevega AL, Dontsova OA, Sergiev PV, Osterman IA, Polikanov YS. Khabibullina NF, et al. Among authors: syroegin ea. Antimicrob Agents Chemother. 2019 May 24;63(6):e02266-18. doi: 10.1128/AAC.02266-18. Print 2019 Jun. Antimicrob Agents Chemother. 2019. PMID: 30936109 Free PMC article.
Erratum for Khabibullina et al., "Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides".
Khabibullina NF, Tereshchenkov AG, Komarova ES, Syroegin EA, Shiriaev DI, Paleskava A, Kartsev VG, Bogdanov AA, Konevega AL, Dontsova OA, Sergiev PV, Osterman IA, Polikanov YS. Khabibullina NF, et al. Among authors: syroegin ea. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e02360-19. doi: 10.1128/AAC.02360-19. Print 2020 Jan 27. Antimicrob Agents Chemother. 2020. PMID: 31988110 Free PMC article. No abstract available.
Peptide Inhibitors of Bacterial Protein Synthesis with Broad Spectrum and SbmA-Independent Bactericidal Activity against Clinical Pathogens.
Mardirossian M, Sola R, Beckert B, Valencic E, Collis DWP, Borišek J, Armas F, Di Stasi A, Buchmann J, Syroegin EA, Polikanov YS, Magistrato A, Hilpert K, Wilson DN, Scocchi M. Mardirossian M, et al. Among authors: syroegin ea. J Med Chem. 2020 Sep 10;63(17):9590-9602. doi: 10.1021/acs.jmedchem.0c00665. Epub 2020 Aug 13. J Med Chem. 2020. PMID: 32787108 Free article.
Practical Synthesis of N-Formylmethionylated Peptidyl-tRNA Mimics.
Thaler J, Syroegin EA, Breuker K, Polikanov YS, Micura R. Thaler J, et al. Among authors: syroegin ea. ACS Chem Biol. 2023 Oct 20;18(10):2233-2239. doi: 10.1021/acschembio.3c00237. Epub 2023 Jul 11. ACS Chem Biol. 2023. PMID: 37433044 Free PMC article.
An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.
Wu KJY, Tresco BIC, Ramkissoon A, Aleksandrova EV, Syroegin EA, See DNY, Liow P, Dittemore GA, Yu M, Testolin G, Mitcheltree MJ, Liu RY, Svetlov MS, Polikanov YS, Myers AG. Wu KJY, et al. Among authors: syroegin ea. Science. 2024 Feb 16;383(6684):721-726. doi: 10.1126/science.adk8013. Epub 2024 Feb 15. Science. 2024. PMID: 38359125
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