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Conformational changes in BAK, a pore-forming proapoptotic Bcl-2 family member, upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers.
Oh KJ, Singh P, Lee K, Foss K, Lee S, Park M, Lee S, Aluvila S, Park M, Singh P, Kim RS, Symersky J, Walters DE. Oh KJ, et al. Among authors: symersky j. J Biol Chem. 2010 Sep 10;285(37):28924-37. doi: 10.1074/jbc.M110.135293. Epub 2010 Jul 6. J Biol Chem. 2010. PMID: 20605789 Free PMC article.
Oligomycin frames a common drug-binding site in the ATP synthase.
Symersky J, Osowski D, Walters DE, Mueller DM. Symersky J, et al. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):13961-5. doi: 10.1073/pnas.1207912109. Epub 2012 Aug 6. Proc Natl Acad Sci U S A. 2012. PMID: 22869738 Free PMC article.
Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM.
Rich RL, Deivanayagam CC, Owens RT, Carson M, Höök A, Moore D, Symersky J, Yang VW, Narayana SV, Höök M. Rich RL, et al. Among authors: symersky j. J Biol Chem. 1999 Aug 27;274(35):24906-13. doi: 10.1074/jbc.274.35.24906. J Biol Chem. 1999. PMID: 10455165 Free article.
This trench can accommodate a collagen triple-helical structure and presumably represents the ligand-binding site (Emsley, J., King, S. L., Bergelson, J. M., and Liddington, R. C. (1997) J. Biol. Chem. 272, 28512-28517; Symersky, J., Patti, J …
This trench can accommodate a collagen triple-helical structure and presumably represents the ligand-binding site (Emsley, J., King, …
Bedaquiline inhibits the yeast and human mitochondrial ATP synthases.
Luo M, Zhou W, Patel H, Srivastava AP, Symersky J, Bonar MM, Faraldo-Gómez JD, Liao M, Mueller DM. Luo M, et al. Among authors: symersky j. Commun Biol. 2020 Aug 19;3(1):452. doi: 10.1038/s42003-020-01173-z. Commun Biol. 2020. PMID: 32814813 Free PMC article.
39 results