Sykes MJ - Search Results

1

In Search of Novel CDK8 Inhibitors by Virtual Screening.

Kumarasiri M, Teo T, Yu M, Philip S, Basnet SK, Albrecht H, Sykes MJ, Wang P, Wang S. Kumarasiri M, et al. Among authors: sykes mj. J Chem Inf Model. 2017 Mar 27;57(3):413-416. doi: 10.1021/acs.jcim.6b00711. Epub 2017 Feb 16. J Chem Inf Model. 2017. PMID: 28191946

2

Molecular modeling approaches for the prediction of the nonspecific binding of drugs to hepatic microsomes.

Sykes MJ, Sorich MJ, Miners JO. Sykes MJ, et al. J Chem Inf Model. 2006 Nov-Dec;46(6):2661-73. doi: 10.1021/ci600221h. J Chem Inf Model. 2006. PMID: 17125206

3

Identification of a novel oligomerization disrupting mutation in CRYΑA associated with congenital cataract in a South Australian family.

Laurie KJ, Dave A, Straga T, Souzeau E, Chataway T, Sykes MJ, Casey T, Teo T, Pater J, Craig JE, Sharma S, Burdon KP. Laurie KJ, et al. Among authors: sykes mj. Hum Mutat. 2013 Mar;34(3):435-8. doi: 10.1002/humu.22260. Epub 2013 Jan 17. Hum Mutat. 2013. PMID: 23255486

4

Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation.

Diab S, Teo T, Kumarasiri M, Li P, Yu M, Lam F, Basnet SK, Sykes MJ, Albrecht H, Milne R, Wang S. Diab S, et al. Among authors: sykes mj. ChemMedChem. 2014 May;9(5):962-72. doi: 10.1002/cmdc.201300552. Epub 2014 Feb 12. ChemMedChem. 2014. PMID: 24677692

5

Insights into the Importance of DFD-Motif and Insertion I1 in Stabilizing the DFD-Out Conformation of Mnk2 Kinase.

Hou J, Teo T, Sykes MJ, Wang S. Hou J, et al. Among authors: sykes mj. ACS Med Chem Lett. 2013 Jun 24;4(8):736-41. doi: 10.1021/ml400145x. eCollection 2013 Aug 8. ACS Med Chem Lett. 2013. PMID: 24900740 Free PMC article.

6

Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.

Teo T, Yu M, Yang Y, Gillam T, Lam F, Sykes MJ, Wang S. Teo T, et al. Among authors: sykes mj. Cancer Lett. 2015 Feb 28;357(2):612-23. doi: 10.1016/j.canlet.2014.12.029. Epub 2014 Dec 16. Cancer Lett. 2015. PMID: 25527453

7

Targeting Pim kinases for cancer treatment: opportunities and challenges.

Le BT, Kumarasiri M, Adams JR, Yu M, Milne R, Sykes MJ, Wang S. Le BT, et al. Among authors: sykes mj. Future Med Chem. 2015;7(1):35-53. doi: 10.4155/fmc.14.145. Future Med Chem. 2015. PMID: 25582332 Review.

8

Pharmacologic Inhibition of MNKs in Acute Myeloid Leukemia.

Teo T, Lam F, Yu M, Yang Y, Basnet SK, Albrecht H, Sykes MJ, Wang S. Teo T, et al. Among authors: sykes mj. Mol Pharmacol. 2015 Aug;88(2):380-9. doi: 10.1124/mol.115.098012. Epub 2015 Jun 4. Mol Pharmacol. 2015. PMID: 26044548

9

An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis.

Teo T, Yang Y, Yu M, Basnet SK, Gillam T, Hou J, Schmid RM, Kumarasiri M, Diab S, Albrecht H, Sykes MJ, Wang S. Teo T, et al. Among authors: sykes mj. Eur J Med Chem. 2015 Oct 20;103:539-50. doi: 10.1016/j.ejmech.2015.09.008. Epub 2015 Sep 9. Eur J Med Chem. 2015. PMID: 26408454

10

Discovery of CDK5 Inhibitors through Structure-Guided Approach.

Khair NZ, Lenjisa JL, Tadesse S, Kumarasiri M, Basnet SKC, Mekonnen LB, Li M, Diab S, Sykes MJ, Albrecht H, Milne R, Wang S. Khair NZ, et al. Among authors: sykes mj. ACS Med Chem Lett. 2019 Mar 20;10(5):786-791. doi: 10.1021/acsmedchemlett.9b00029. eCollection 2019 May 9. ACS Med Chem Lett. 2019. PMID: 31098000 Free PMC article.

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