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Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release.
Simon JN, Vrellaku B, Monterisi S, Chu SM, Rawlings N, Lomas O, Marchal GA, Waithe D, Syeda F, Gajendragadkar PR, Jayaram R, Sayeed R, Channon KM, Fabritz L, Swietach P, Zaccolo M, Eaton P, Casadei B. Simon JN, et al. Among authors: swietach p. Circulation. 2021 Feb 2;143(5):449-465. doi: 10.1161/CIRCULATIONAHA.120.046761. Epub 2020 Nov 13. Circulation. 2021. PMID: 33185461 Free PMC article.
How protons pave the way to aggressive cancers.
Swietach P, Boedtkjer E, Pedersen SF. Swietach P, et al. Nat Rev Cancer. 2023 Dec;23(12):825-841. doi: 10.1038/s41568-023-00628-9. Epub 2023 Oct 26. Nat Rev Cancer. 2023. PMID: 37884609 Review.
Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane.
Burdyga A, Surdo NC, Monterisi S, Di Benedetto G, Grisan F, Penna E, Pellegrini L, Zaccolo M, Bortolozzi M, Swietach P, Pozzan T, Lefkimmiatis K. Burdyga A, et al. Among authors: swietach p. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6497-E6506. doi: 10.1073/pnas.1806318115. Epub 2018 Jun 25. Proc Natl Acad Sci U S A. 2018. PMID: 29941564 Free PMC article.
Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH.
Wilson AD, Richards MA, Curtis MK, Gunadasa-Rohling M, Monterisi S, Loonat AA, Miller JJ, Ball V, Lewis A, Tyler DJ, Moshnikova A, Andreev OA, Reshetnyak YK, Carr C, Swietach P. Wilson AD, et al. Among authors: swietach p. Cardiovasc Res. 2022 Nov 10;118(14):2946-2959. doi: 10.1093/cvr/cvab364. Cardiovasc Res. 2022. PMID: 34897412 Free PMC article.
102 results