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The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity.
Elena-Real CA, Sagar A, Urbanek A, Popovic M, Morató A, Estaña A, Fournet A, Doucet C, Lund XL, Shi ZD, Costa L, Thureau A, Allemand F, Swenson RE, Milhiet PE, Crehuet R, Barducci A, Cortés J, Sinnaeve D, Sibille N, Bernadó P. Elena-Real CA, et al. Among authors: swenson re. Nat Struct Mol Biol. 2023 Mar;30(3):309-320. doi: 10.1038/s41594-023-00920-0. Epub 2023 Mar 2. Nat Struct Mol Biol. 2023. PMID: 36864173
Synthesis and Evaluation of Fluorine-18-Labeled L-Rhamnose Derivatives.
Zhang X, Basuli F, Shi ZD, Shah S, Shi J, Mitchell A, Lai J, Wang Z, Hammoud DA, Swenson RE. Zhang X, et al. Among authors: swenson re. Molecules. 2023 Apr 27;28(9):3773. doi: 10.3390/molecules28093773. Molecules. 2023. PMID: 37175182 Free PMC article.
Dietary fish oil enriched in very-long-chain polyunsaturated fatty acid reduces cardiometabolic risk factors and improves retinal function.
Yang ZH, Gorusupudi A, Lydic TA, Mondal AK, Sato S, Yamazaki I, Yamaguchi H, Tang J, Rojulpote KV, Lin AB, Decot H, Koch H, Brock DC, Arunkumar R, Shi ZD, Yu ZX, Pryor M, Kun JF, Swenson RE, Swaroop A, Bernstein PS, Remaley AT. Yang ZH, et al. Among authors: swenson re. iScience. 2023 Nov 7;26(12):108411. doi: 10.1016/j.isci.2023.108411. eCollection 2023 Dec 15. iScience. 2023. PMID: 38047069 Free PMC article.
A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins.
Lu X, Chandravanshi M, Sabbasani VR, Gaikwad S, Hughitt VK, Gyabaah-Kessie N, Scroggins BT, Das S, Myint W, Clapp ME, Schwieters CD, Dyba MA, Bolhuis DL, Koscielniak JW, Andresson T, Emanuele MJ, Brown NG, Matsuo H, Chari R, Citrin DE, Mock BA, Swenson RE, Walters KJ. Lu X, et al. Among authors: swenson re. Nat Commun. 2024 Mar 20;15(1):2485. doi: 10.1038/s41467-024-46644-7. Nat Commun. 2024. PMID: 38509117 Free PMC article.
hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50.
Osei-Amponsa V, Chandravanshi M, Lu X, Magidson V, Das S, Andresson T, Dyba M, Sabbasani VR, Swenson RE, Fromont C, Shrestha B, Zhao Y, Clapp ME, Chari R, Walters KJ. Osei-Amponsa V, et al. Among authors: swenson re. Mol Cell. 2024 Feb 1;84(3):522-537.e8. doi: 10.1016/j.molcel.2023.11.035. Epub 2023 Dec 26. Mol Cell. 2024. PMID: 38151017
Site-Specifically Conjugated Single-Domain Antibody Successfully Identifies Glypican-3-Expressing Liver Cancer by Immuno-PET.
Fayn S, King AP, Gutsche NT, Duan Z, Buffington J, Olkowski CP, Fu Y, Hong J, Sail D, Baidoo KE, Swenson RE, Cheloha RW, Ho M, Choyke PL, Escorcia FE. Fayn S, et al. Among authors: swenson re. J Nucl Med. 2023 Jul;64(7):1017-1023. doi: 10.2967/jnumed.122.265171. Epub 2023 Mar 30. J Nucl Med. 2023. PMID: 36997331 Free PMC article.
Tools and tactics to define specificity of metabolic chemical reporters.
Mukherjee MM, Bond MR, Abramowitz LK, Biesbrock D, Woodroofe CC, Kim EJ, Swenson RE, Hanover JA. Mukherjee MM, et al. Among authors: swenson re. Front Mol Biosci. 2023 Dec 7;10:1286690. doi: 10.3389/fmolb.2023.1286690. eCollection 2023. Front Mol Biosci. 2023. PMID: 38143802 Free PMC article.
96 results