Sweasy JB - Search Results

1

Interplay between DNA repair and inflammation, and the link to cancer.

Kidane D, Chae WJ, Czochor J, Eckert KA, Glazer PM, Bothwell AL, Sweasy JB. Kidane D, et al. Among authors: sweasy jb. Crit Rev Biochem Mol Biol. 2014 Mar-Apr;49(2):116-39. doi: 10.3109/10409238.2013.875514. Epub 2014 Jan 13. Crit Rev Biochem Mol Biol. 2014. PMID: 24410153 Free PMC article. Review.

2

A genetic system to identify DNA polymerase beta mutator mutants.

Washington SL, Yoon MS, Chagovetz AM, Li SX, Clairmont CA, Preston BD, Eckert KA, Sweasy JB. Washington SL, et al. Among authors: sweasy jb. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1321-6. doi: 10.1073/pnas.94.4.1321. Proc Natl Acad Sci U S A. 1997. PMID: 9037051 Free PMC article.

3

The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors.

Opresko PL, Sweasy JB, Eckert KA. Opresko PL, et al. Among authors: sweasy jb. Biochemistry. 1998 Feb 24;37(8):2111-9. doi: 10.1021/bi9722711. Biochemistry. 1998. PMID: 9485358

4

The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells.

Clairmont CA, Narayanan L, Sun KW, Glazer PM, Sweasy JB. Clairmont CA, et al. Among authors: sweasy jb. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9580-5. doi: 10.1073/pnas.96.17.9580. Proc Natl Acad Sci U S A. 1999. PMID: 10449735 Free PMC article.

5

Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site.

Maitra M, Gudzelak A Jr, Li SX, Matsumoto Y, Eckert KA, Jager J, Sweasy JB. Maitra M, et al. Among authors: sweasy jb. J Biol Chem. 2002 Sep 20;277(38):35550-60. doi: 10.1074/jbc.M204953200. Epub 2002 Jul 16. J Biol Chem. 2002. PMID: 12121998 Free article.

6

Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator.

Dalal S, Hile S, Eckert KA, Sun KW, Starcevic D, Sweasy JB. Dalal S, et al. Among authors: sweasy jb. Biochemistry. 2005 Dec 6;44(48):15664-73. doi: 10.1021/bi051179z. Biochemistry. 2005. PMID: 16313169

7

DNA polymerases and human diseases.

Sweasy JB, Lauper JM, Eckert KA. Sweasy JB, et al. Radiat Res. 2006 Nov;166(5):693-714. doi: 10.1667/RR0706.1. Radiat Res. 2006. PMID: 17067213 Review.

8

The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation.

Lang T, Dalal S, Chikova A, DiMaio D, Sweasy JB. Lang T, et al. Among authors: sweasy jb. Mol Cell Biol. 2007 Aug;27(15):5587-96. doi: 10.1128/MCB.01883-06. Epub 2007 May 25. Mol Cell Biol. 2007. PMID: 17526740 Free PMC article.

9

Loop II of DNA polymerase beta is important for discrimination during substrate binding.

Lin GC, Jaeger J, Eckert KA, Sweasy JB. Lin GC, et al. Among authors: sweasy jb. DNA Repair (Amst). 2009 Feb 1;8(2):182-9. doi: 10.1016/j.dnarep.2008.10.006. Epub 2008 Dec 5. DNA Repair (Amst). 2009. PMID: 19013261 Free PMC article.

10

Sequence context-specific mutagenesis and base excision repair.

Donigan KA, Sweasy JB. Donigan KA, et al. Among authors: sweasy jb. Mol Carcinog. 2009 Apr;48(4):362-8. doi: 10.1002/mc.20497. Mol Carcinog. 2009. PMID: 19306280 Free PMC article. Review.

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