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Mechanical memory stored through epigenetic remodeling reduces cell therapeutic potential.
Scott AK, Casas E, Schneider SE, Swearingen AR, Van Den Elzen CL, Seelbinder B, Barthold JE, Kugel JF, Stern JL, Foster KJ, Emery NC, Brumbaugh J, Neu CP. Scott AK, et al. Among authors: swearingen ar. Biophys J. 2023 Apr 18;122(8):1428-1444. doi: 10.1016/j.bpj.2023.03.004. Epub 2023 Mar 4. Biophys J. 2023. PMID: 36871159 Free PMC article.
Nuclear deformation guides chromatin reorganization in cardiac development and disease.
Seelbinder B, Ghosh S, Schneider SE, Scott AK, Berman AG, Goergen CJ, Margulies KB, Bedi KC Jr, Casas E, Swearingen AR, Brumbaugh J, Calve S, Neu CP. Seelbinder B, et al. Among authors: swearingen ar. Nat Biomed Eng. 2021 Dec;5(12):1500-1516. doi: 10.1038/s41551-021-00823-9. Epub 2021 Dec 2. Nat Biomed Eng. 2021. PMID: 34857921 Free PMC article.
Genome-wide binding analysis of 195 DNA binding proteins reveals "reservoir" promoters and human specific SVA-repeat family regulation.
Smallegan MJ, Shehata S, Spradlin SF, Swearingen A, Wheeler G, Das A, Corbet G, Nebenfuehr B, Ahrens D, Tauber D, Lennon S, Choi K, Huynh T, Wieser T, Schneider K, Bradshaw M, Basken J, Lai M, Read T, Hynes-Grace M, Timmons D, Demasi J, Rinn JL. Smallegan MJ, et al. PLoS One. 2021 Jun 24;16(6):e0237055. doi: 10.1371/journal.pone.0237055. eCollection 2021. PLoS One. 2021. PMID: 34166368 Free PMC article.