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α-Lactam Electrophiles for Covalent Chemical Biology.
Mahía A, Kiib AE, Nisavic M, Svenningsen EB, Palmfeldt J, Poulsen TB. Mahía A, et al. Among authors: svenningsen eb. Angew Chem Int Ed Engl. 2023 Jun 26;62(26):e202304142. doi: 10.1002/anie.202304142. Epub 2023 May 15. Angew Chem Int Ed Engl. 2023. PMID: 37114559
The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21.
Svenningsen EB, Ottosen RN, Jørgensen KH, Nisavic M, Larsen CK, Hansen BK, Wang Y, Lindorff-Larsen K, Tørring T, Hacker SM, Palmfeldt J, Poulsen TB. Svenningsen EB, et al. RSC Chem Biol. 2022 Sep 7;3(10):1216-1229. doi: 10.1039/d2cb00161f. eCollection 2022 Oct 5. RSC Chem Biol. 2022. PMID: 36320884 Free PMC article.
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity.
Casares L, Moreno R, Ali KX, Higgins M, Dayalan Naidu S, Neill G, Cassin L, Kiib AE, Svenningsen EB, Minassi A, Honda T, Poulsen TB, Wiel C, Sayin VI, Dinkova-Kostova AT, Olagnier D, de la Vega L. Casares L, et al. Among authors: svenningsen eb. Redox Biol. 2022 May;51:102291. doi: 10.1016/j.redox.2022.102291. Epub 2022 Mar 17. Redox Biol. 2022. PMID: 35313207 Free PMC article.
Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro.
Svenningsen EB, Thyrsted J, Blay-Cadanet J, Liu H, Lin S, Moyano-Villameriel J, Olagnier D, Idorn M, Paludan SR, Holm CK, Poulsen TB. Svenningsen EB, et al. Antiviral Res. 2021 Jan;185:104988. doi: 10.1016/j.antiviral.2020.104988. Epub 2020 Nov 25. Antiviral Res. 2021. PMID: 33248195 Free PMC article.
Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
Olagnier D, Farahani E, Thyrsted J, Blay-Cadanet J, Herengt A, Idorn M, Hait A, Hernaez B, Knudsen A, Iversen MB, Schilling M, Jørgensen SE, Thomsen M, Reinert LS, Lappe M, Hoang HD, Gilchrist VH, Hansen AL, Ottosen R, Nielsen CG, Møller C, van der Horst D, Peri S, Balachandran S, Huang J, Jakobsen M, Svenningsen EB, Poulsen TB, Bartsch L, Thielke AL, Luo Y, Alain T, Rehwinkel J, Alcamí A, Hiscott J, Mogensen TH, Paludan SR, Holm CK. Olagnier D, et al. Among authors: svenningsen eb. Nat Commun. 2020 Oct 21;11(1):5419. doi: 10.1038/s41467-020-19363-y. Nat Commun. 2020. PMID: 33087717 Free PMC article.
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