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Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects.
Workman MJ, Lim RG, Wu J, Frank A, Ornelas L, Panther L, Galvez E, Perez D, Meepe I, Lei S, Valencia V, Gomez E, Liu C, Moran R, Pinedo L, Tsitkov S, Ho R, Kaye JA; Answer ALS Consortium; Thompson T, Rothstein JD, Finkbeiner S, Fraenkel E, Sareen D, Thompson LM, Svendsen CN. Workman MJ, et al. Among authors: svendsen cn. Neuron. 2023 Apr 19;111(8):1191-1204.e5. doi: 10.1016/j.neuron.2023.01.010. Epub 2023 Feb 9. Neuron. 2023. PMID: 36764301 Free PMC article.
Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration.
Laperle AH, Moser VA, Avalos P, Lu B, Wu A, Fulton A, Ramirez S, Garcia VJ, Bell S, Ho R, Lawless G, Roxas K, Shahin S, Shelest O, Svendsen S, Wang S, Svendsen CN. Laperle AH, et al. Among authors: svendsen s, svendsen cn. Stem Cell Reports. 2023 Aug 8;18(8):1629-1642. doi: 10.1016/j.stemcr.2023.03.016. Epub 2023 Apr 20. Stem Cell Reports. 2023. PMID: 37084724 Free PMC article.
GMP-grade human neural progenitors delivered subretinally protect vision in rat model of retinal degeneration and survive in minipigs.
Lu B, Avalos P, Svendsen S, Zhang C, Nocito L, Jones MK, Pieplow C, Saylor J, Ghiam S, Block A, Fernandez M, Ljubimov AV, Small K, Liao D, Svendsen CN, Wang S. Lu B, et al. Among authors: svendsen cn. J Transl Med. 2023 Sep 25;21(1):650. doi: 10.1186/s12967-023-04501-z. J Transl Med. 2023. PMID: 37743503 Free PMC article.
Translational roadmap for regenerative therapies of eye disease.
Levin LA, Chiang MF, Dyer MA, Greenwell TN, Svendsen CN, Tumminia SJ, Van Gelder RN, Wong RO. Levin LA, et al. Among authors: svendsen cn. Med. 2023 Sep 8;4(9):583-590. doi: 10.1016/j.medj.2023.06.005. Med. 2023. PMID: 37689055
Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells.
Shah R, Spektor TM, Weisenberger DJ, Ding H, Patil R, Amador C, Song XY, Chun ST, Inzalaco J, Turjman S, Ghiam S, Jeong-Kim J, Tolstoff S, Yampolsky SV, Sawant OB, Rabinowitz YS, Maguen E, Hamrah P, Svendsen CN, Saghizadeh M, Ljubimova JY, Kramerov AA, Ljubimov AV. Shah R, et al. Among authors: svendsen cn. Diabetologia. 2023 Oct;66(10):1943-1958. doi: 10.1007/s00125-023-05960-1. Epub 2023 Jul 18. Diabetologia. 2023. PMID: 37460827 Free PMC article.
SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys.
Aggarwal S, Wang Z, Rincon Fernandez Pacheco D, Rinaldi A, Rajewski A, Callemeyn J, Van Loon E, Lamarthée B, Covarrubias AE, Hou J, Yamashita M, Akiyama H, Karumanchi SA, Svendsen CN, Noble PW, Jordan SC, Breunig JJ, Naesens M, Cippà PE, Kumar S. Aggarwal S, et al. Among authors: svendsen cn. Science. 2024 Feb 23;383(6685):eadd6371. doi: 10.1126/science.add6371. Epub 2024 Feb 23. Science. 2024. PMID: 38386758
Multi-lineage heart-chip models drug cardiotoxicity and enhances maturation of human stem cell-derived cardiovascular cells.
Mozneb M, Jenkins A, Sances S, Pohlman S, Workman MJ, West D, Ondatje B, El-Ghazawi K, Woodbury A, Garcia VJ, Patel S, Arzt M, Dezem F, Laperle AH, Moser VA, Ho R, Yucer N, Plummer J, Barrett RJ, Svendsen CN, Sharma A. Mozneb M, et al. Among authors: svendsen cn. Lab Chip. 2024 Feb 13;24(4):869-881. doi: 10.1039/d3lc00745f. Lab Chip. 2024. PMID: 38252454
247 results