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Structural basis of pharmacological chaperoning for human β-galactosidase.
Suzuki H, Ohto U, Higaki K, Mena-Barragán T, Aguilar-Moncayo M, Ortiz Mellet C, Nanba E, Garcia Fernandez JM, Suzuki Y, Shimizu T. Suzuki H, et al. Among authors: suzuki y. J Biol Chem. 2014 May 23;289(21):14560-8. doi: 10.1074/jbc.M113.529529. Epub 2014 Apr 15. J Biol Chem. 2014. PMID: 24737316 Free PMC article.
A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis.
Takai T, Higaki K, Aguilar-Moncayo M, Mena-Barragán T, Hirano Y, Yura K, Yu L, Ninomiya H, García-Moreno MI, Sakakibara Y, Ohno K, Nanba E, Ortiz Mellet C, García Fernández JM, Suzuki Y. Takai T, et al. Among authors: suzuki y. Mol Ther. 2013 Mar;21(3):526-32. doi: 10.1038/mt.2012.263. Epub 2013 Jan 22. Mol Ther. 2013. PMID: 23337983 Free PMC article.
Molecular basis of 1-deoxygalactonojirimycin arylthiourea binding to human α-galactosidase a: pharmacological chaperoning efficacy on Fabry disease mutants.
Yu Y, Mena-Barragán T, Higaki K, Johnson JL, Drury JE, Lieberman RL, Nakasone N, Ninomiya H, Tsukimura T, Sakuraba H, Suzuki Y, Nanba E, Mellet CO, García Fernández JM, Ohno K. Yu Y, et al. Among authors: suzuki y. ACS Chem Biol. 2014 Jul 18;9(7):1460-9. doi: 10.1021/cb500143h. Epub 2014 May 12. ACS Chem Biol. 2014. PMID: 24783948
pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases.
Mena-Barragán T, Narita A, Matias D, Tiscornia G, Nanba E, Ohno K, Suzuki Y, Higaki K, Garcia Fernández JM, Ortiz Mellet C. Mena-Barragán T, et al. Among authors: suzuki y. Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11696-700. doi: 10.1002/anie.201505147. Epub 2015 Aug 7. Angew Chem Int Ed Engl. 2015. PMID: 26386364
Fibroblast screening for chaperone therapy in beta-galactosidosis.
Iwasaki H, Watanabe H, Iida M, Ogawa S, Tabe M, Higaki K, Nanba E, Suzuki Y. Iwasaki H, et al. Among authors: suzuki y. Brain Dev. 2006 Sep;28(8):482-6. doi: 10.1016/j.braindev.2006.02.002. Epub 2006 Apr 17. Brain Dev. 2006. PMID: 16617000
Chemical chaperone therapy: clinical effect in murine G(M1)-gangliosidosis.
Suzuki Y, Ichinomiya S, Kurosawa M, Ohkubo M, Watanabe H, Iwasaki H, Matsuda J, Noguchi Y, Takimoto K, Itoh M, Tabe M, Iida M, Kubo T, Ogawa S, Nanba E, Higaki K, Ohno K, Brady RO. Suzuki Y, et al. Ann Neurol. 2007 Dec;62(6):671-5. doi: 10.1002/ana.21284. Ann Neurol. 2007. PMID: 17994547
Enhanced autophagy and mitochondrial aberrations in murine G(M1)-gangliosidosis.
Takamura A, Higaki K, Kajimaki K, Otsuka S, Ninomiya H, Matsuda J, Ohno K, Suzuki Y, Nanba E. Takamura A, et al. Among authors: suzuki y. Biochem Biophys Res Commun. 2008 Mar 14;367(3):616-22. doi: 10.1016/j.bbrc.2007.12.187. Epub 2008 Jan 9. Biochem Biophys Res Commun. 2008. PMID: 18190792
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