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Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation.
Dagvadorj J, Mikulska-Ruminska K, Tumurkhuu G, Ratsimandresy RA, Carriere J, Andres AM, Marek-Iannucci S, Song Y, Chen S, Lane M, Dorfleutner A, Gottlieb RA, Stehlik C, Cassel S, Sutterwala FS, Bahar I, Crother TR, Arditi M. Dagvadorj J, et al. Among authors: sutterwala fs. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2015632118. doi: 10.1073/pnas.2015632118. Proc Natl Acad Sci U S A. 2021. PMID: 33361152 Free PMC article.
Sensing damage by the NLRP3 inflammasome.
Leemans JC, Cassel SL, Sutterwala FS. Leemans JC, et al. Among authors: sutterwala fs. Immunol Rev. 2011 Sep;243(1):152-62. doi: 10.1111/j.1600-065X.2011.01043.x. Immunol Rev. 2011. PMID: 21884174 Free PMC article. Review.
Mechanism of NLRP3 inflammasome activation.
Sutterwala FS, Haasken S, Cassel SL. Sutterwala FS, et al. Ann N Y Acad Sci. 2014 Jun;1319(1):82-95. doi: 10.1111/nyas.12458. Epub 2014 May 19. Ann N Y Acad Sci. 2014. PMID: 24840700 Free PMC article. Review.
The Nalp3 inflammasome is essential for the development of silicosis.
Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS. Cassel SL, et al. Among authors: sutterwala fs. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9035-40. doi: 10.1073/pnas.0803933105. Epub 2008 Jun 24. Proc Natl Acad Sci U S A. 2008. PMID: 18577586 Free PMC article.
Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice.
Cassel SL, Janczy JR, Bing X, Wilson SP, Olivier AK, Otero JE, Iwakura Y, Shayakhmetov DM, Bassuk AG, Abu-Amer Y, Brogden KA, Burns TL, Sutterwala FS, Ferguson PJ. Cassel SL, et al. Among authors: sutterwala fs. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1072-7. doi: 10.1073/pnas.1318685111. Epub 2014 Jan 6. Proc Natl Acad Sci U S A. 2014. PMID: 24395802 Free PMC article.
Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation.
Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK, Sadler JJ, Knepper-Adrian V, Han R, Qiao L, Eisenbarth SC, Nauseef WM, Cassel SL, Sutterwala FS. Iyer SS, et al. Among authors: sutterwala fs. Immunity. 2013 Aug 22;39(2):311-323. doi: 10.1016/j.immuni.2013.08.001. Epub 2013 Aug 15. Immunity. 2013. PMID: 23954133 Free PMC article.
114 results