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Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities.
Boshoff HIM, Young K, Ahn YM, Yadav VD, Crowley BM, Yang L, Su J, Oh S, Arora K, Andrews J, Manikkam M, Sutphin M, Smith AJ, Weiner DM, Piazza MK, Fleegle JD, Gomez F, Dayao EK, Prideaux B, Zimmerman M, Kaya F, Sarathy J, Tan VY, Via LE, Tschirret-Guth R, Lenaerts AJ, Robertson GT, Dartois V, Olsen DB, Barry CE 3rd. Boshoff HIM, et al. Among authors: sutphin m. ACS Infect Dis. 2024 May 10;10(5):1679-1695. doi: 10.1021/acsinfecdis.4c00025. Epub 2024 Apr 6. ACS Infect Dis. 2024. PMID: 38581700
Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.
Oh S, Park Y, Engelhart CA, Wallach JB, Schnappinger D, Arora K, Manikkam M, Gac B, Wang H, Murgolo N, Olsen DB, Goodwin M, Sutphin M, Weiner DM, Via LE, Boshoff HIM, Barry CE 3rd. Oh S, et al. Among authors: sutphin m. J Med Chem. 2018 Nov 21;61(22):9952-9965. doi: 10.1021/acs.jmedchem.8b00883. Epub 2018 Nov 5. J Med Chem. 2018. PMID: 30350998 Free PMC article.
Defective positioning in granulomas but not lung-homing limits CD4 T-cell interactions with Mycobacterium tuberculosis-infected macrophages in rhesus macaques.
Kauffman KD, Sallin MA, Sakai S, Kamenyeva O, Kabat J, Weiner D, Sutphin M, Schimel D, Via L, Barry CE 3rd, Wilder-Kofie T, Moore I, Moore R, Barber DL. Kauffman KD, et al. Among authors: sutphin m. Mucosal Immunol. 2018 Mar;11(2):462-473. doi: 10.1038/mi.2017.60. Epub 2017 Jul 26. Mucosal Immunol. 2018. PMID: 28745326 Free PMC article.
Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet.
Merat S, Casanada F, Sutphin M, Palinski W, Reaven PD. Merat S, et al. Among authors: sutphin m. Arterioscler Thromb Vasc Biol. 1999 May;19(5):1223-30. doi: 10.1161/01.atv.19.5.1223. Arterioscler Thromb Vasc Biol. 1999. PMID: 10323773
Carbohydrate-deficient transferrin evaluation in dry blood spots.
Bean P, Sutphin MS, Necessary P, Agopian MS, Liegmann K, Ludvigsen C, Peter JB. Bean P, et al. Among authors: sutphin ms. Alcohol Clin Exp Res. 1996 Feb;20(1):56-60. doi: 10.1111/j.1530-0277.1996.tb01044.x. Alcohol Clin Exp Res. 1996. PMID: 8651463
28 results