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Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes.
Sparbier CE, Gillespie A, Gomez J, Kumari N, Motazedian A, Chan KL, Bell CC, Gilan O, Chan YC, Popp S, Gough DJ, Eckersley-Maslin MA, Dawson SJ, Lehner PJ, Sutherland KD, Ernst P, McGeehan GM, Lam EYN, Burr ML, Dawson MA. Sparbier CE, et al. Among authors: sutherland kd. Nat Cell Biol. 2023 Feb;25(2):258-272. doi: 10.1038/s41556-022-01056-x. Epub 2023 Jan 12. Nat Cell Biol. 2023. PMID: 36635503 Free PMC article.
Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer.
Weeden CE, Gayevskiy V, Marceaux C, Batey D, Tan T, Yokote K, Ribera NT, Clatch A, Christo S, Teh CE, Mitchell AJ, Trussart M, Rankin L, Obers A, McDonald JA, Sutherland KD, Sharma VJ, Starkey G, D'Costa R, Antippa P, Leong T, Steinfort D, Irving L, Swanton C, Gordon CL, Mackay LK, Speed TP, Gray DHD, Asselin-Labat ML. Weeden CE, et al. Among authors: sutherland kd. Cancer Cell. 2023 May 8;41(5):837-852.e6. doi: 10.1016/j.ccell.2023.03.019. Epub 2023 Apr 21. Cancer Cell. 2023. PMID: 37086716 Free article.
Design and characterization of a heterobifunctional degrader of KEAP1.
Chen H, Nguyen NH, Magtoto CM, Cobbold SA, Bidgood GM, Meza Guzman LG, Richardson LW, Corbin J, Au AE, Lechtenberg BC, Feltham R, Sutherland KD, Grohmann C, Nicholson SE, Sleebs BE. Chen H, et al. Among authors: sutherland kd. Redox Biol. 2023 Feb;59:102552. doi: 10.1016/j.redox.2022.102552. Epub 2022 Nov 26. Redox Biol. 2023. PMID: 36473314 Free PMC article.
Next batter up! Targeting cancers with KRAS-G12D mutations.
Zeissig MN, Ashwood LM, Kondrashova O, Sutherland KD. Zeissig MN, et al. Among authors: sutherland kd. Trends Cancer. 2023 Nov;9(11):955-967. doi: 10.1016/j.trecan.2023.07.010. Epub 2023 Aug 15. Trends Cancer. 2023. PMID: 37591766 Free article. Review.
Molecular and Pathologic Characterization of YAP1-Expressing Small Cell Lung Cancer Cell Lines Leads to Reclassification as SMARCA4-Deficient Malignancies.
Ng J, Cai L, Girard L, Prall OWJ, Rajan N, Khoo C, Batrouney A, Byrne DJ, Boyd DK, Kersbergen AJ, Christie M, Minna JD, Burr ML, Sutherland KD. Ng J, et al. Among authors: sutherland kd. Clin Cancer Res. 2024 May 1;30(9):1846-1858. doi: 10.1158/1078-0432.CCR-23-2360. Clin Cancer Res. 2024. PMID: 38180245 Free PMC article.
Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing.
Hiatt JB, Sandborg H, Garrison SM, Arnold HU, Liao SY, Norton JP, Friesen TJ, Wu F, Sutherland KD, Rienhoff HY, Martins R, Houghton AM, Srivastava S, MacPherson D. Hiatt JB, et al. Among authors: sutherland kd. Clin Cancer Res. 2022 Oct 14;28(20):4551-4564. doi: 10.1158/1078-0432.CCR-22-1128. Clin Cancer Res. 2022. PMID: 35920742 Free PMC article.
Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer.
Best SA, Gubser PM, Sethumadhavan S, Kersbergen A, Negrón Abril YL, Goldford J, Sellers K, Abeysekera W, Garnham AL, McDonald JA, Weeden CE, Anderson D, Pirman D, Roddy TP, Creek DJ, Kallies A, Kingsbury G, Sutherland KD. Best SA, et al. Among authors: sutherland kd. Cell Metab. 2022 Jun 7;34(6):874-887.e6. doi: 10.1016/j.cmet.2022.04.003. Epub 2022 May 2. Cell Metab. 2022. PMID: 35504291 Free article.
76 results