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HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Suskiewicz MJ, Zobel F, Ogden TEH, Fontana P, Ariza A, Yang JC, Zhu K, Bracken L, Hawthorne WJ, Ahel D, Neuhaus D, Ahel I. Suskiewicz MJ, et al. Nature. 2020 Mar;579(7800):598-602. doi: 10.1038/s41586-020-2013-6. Epub 2020 Feb 6. Nature. 2020. PMID: 32028527 Free PMC article.
Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.
Bilokapic S, Suskiewicz MJ, Ahel I, Halic M. Bilokapic S, et al. Among authors: suskiewicz mj. Nature. 2020 Sep;585(7826):609-613. doi: 10.1038/s41586-020-2725-7. Epub 2020 Sep 16. Nature. 2020. PMID: 32939087 Free PMC article.
Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease.
Prokhorova E, Agnew T, Wondisford AR, Tellier M, Kaminski N, Beijer D, Holder J, Groslambert J, Suskiewicz MJ, Zhu K, Reber JM, Krassnig SC, Palazzo L, Murphy S, Nielsen ML, Mangerich A, Ahel D, Baets J, O'Sullivan RJ, Ahel I. Prokhorova E, et al. Among authors: suskiewicz mj. Mol Cell. 2021 Jun 17;81(12):2640-2655.e8. doi: 10.1016/j.molcel.2021.04.028. Epub 2021 May 20. Mol Cell. 2021. PMID: 34019811 Free PMC article.
Serine-linked PARP1 auto-modification controls PARP inhibitor response.
Prokhorova E, Zobel F, Smith R, Zentout S, Gibbs-Seymour I, Schützenhofer K, Peters A, Groslambert J, Zorzini V, Agnew T, Brognard J, Nielsen ML, Ahel D, Huet S, Suskiewicz MJ, Ahel I. Prokhorova E, et al. Among authors: suskiewicz mj. Nat Commun. 2021 Jul 1;12(1):4055. doi: 10.1038/s41467-021-24361-9. Nat Commun. 2021. PMID: 34210965 Free PMC article.
Serine ADP-ribosylation in DNA-damage response regulation.
Palazzo L, Suskiewicz MJ, Ahel I. Palazzo L, et al. Among authors: suskiewicz mj. Curr Opin Genet Dev. 2021 Dec;71:106-113. doi: 10.1016/j.gde.2021.07.005. Epub 2021 Jul 31. Curr Opin Genet Dev. 2021. PMID: 34340015 Free article. Review.
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