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Aprotinin prevents proteolytic epithelial sodium channel (ENaC) activation and volume retention in nephrotic syndrome.
Bohnert BN, Menacher M, Janessa A, Wörn M, Schork A, Daiminger S, Kalbacher H, Häring HU, Daniel C, Amann K, Sure F, Bertog M, Haerteis S, Korbmacher C, Artunc F. Bohnert BN, et al. Among authors: sure f. Kidney Int. 2018 Jan;93(1):159-172. doi: 10.1016/j.kint.2017.07.023. Epub 2017 Oct 14. Kidney Int. 2018. PMID: 29042083 Free article.
Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.
Bohnert BN, Daiminger S, Wörn M, Sure F, Staudner T, Ilyaskin AV, Batbouta F, Janessa A, Schneider JC, Essigke D, Kanse S, Haerteis S, Korbmacher C, Artunc F. Bohnert BN, et al. Among authors: sure f. Acta Physiol (Oxf). 2019 Dec;227(4):e13286. doi: 10.1111/apha.13286. Epub 2019 May 20. Acta Physiol (Oxf). 2019. PMID: 31006168
Proteolytic activation of the epithelial sodium channel (ENaC) by factor VII activating protease (FSAP) and its relevance for sodium retention in nephrotic mice.
Artunc F, Bohnert BN, Schneider JC, Staudner T, Sure F, Ilyaskin AV, Wörn M, Essigke D, Janessa A, Nielsen NV, Birkenfeld AL, Etscheid M, Haerteis S, Korbmacher C, Kanse SM. Artunc F, et al. Among authors: sure f. Pflugers Arch. 2022 Feb;474(2):217-229. doi: 10.1007/s00424-021-02639-7. Epub 2021 Dec 6. Pflugers Arch. 2022. PMID: 34870751 Free PMC article.