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Bile acids inhibit human purinergic receptor P2X4 in a heterologous expression system.
J Gen Physiol. 2019 Jun 3;151(6):820-833. doi: 10.1085/jgp.201812291. Epub 2019 Apr 15.
J Gen Physiol. 2019.
PMID: 30988062
Free PMC article.
Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel's γ-subunit.
Sure F, Bertog M, Afonso S, Diakov A, Rinke R, Madej MG, Wittmann S, Gramberg T, Korbmacher C, Ilyaskin AV.
Sure F, et al.
J Biol Chem. 2022 Jun;298(6):102004. doi: 10.1016/j.jbc.2022.102004. Epub 2022 Apr 30.
J Biol Chem. 2022.
PMID: 35504352
Free PMC article.
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Aprotinin prevents proteolytic epithelial sodium channel (ENaC) activation and volume retention in nephrotic syndrome.
Bohnert BN, Menacher M, Janessa A, Wörn M, Schork A, Daiminger S, Kalbacher H, Häring HU, Daniel C, Amann K, Sure F, Bertog M, Haerteis S, Korbmacher C, Artunc F.
Bohnert BN, et al. Among authors: sure f.
Kidney Int. 2018 Jan;93(1):159-172. doi: 10.1016/j.kint.2017.07.023. Epub 2017 Oct 14.
Kidney Int. 2018.
PMID: 29042083
Free article.
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Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.
Bohnert BN, Daiminger S, Wörn M, Sure F, Staudner T, Ilyaskin AV, Batbouta F, Janessa A, Schneider JC, Essigke D, Kanse S, Haerteis S, Korbmacher C, Artunc F.
Bohnert BN, et al. Among authors: sure f.
Acta Physiol (Oxf). 2019 Dec;227(4):e13286. doi: 10.1111/apha.13286. Epub 2019 May 20.
Acta Physiol (Oxf). 2019.
PMID: 31006168
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Proteolytic activation of the epithelial sodium channel (ENaC) by factor VII activating protease (FSAP) and its relevance for sodium retention in nephrotic mice.
Artunc F, Bohnert BN, Schneider JC, Staudner T, Sure F, Ilyaskin AV, Wörn M, Essigke D, Janessa A, Nielsen NV, Birkenfeld AL, Etscheid M, Haerteis S, Korbmacher C, Kanse SM.
Artunc F, et al. Among authors: sure f.
Pflugers Arch. 2022 Feb;474(2):217-229. doi: 10.1007/s00424-021-02639-7. Epub 2021 Dec 6.
Pflugers Arch. 2022.
PMID: 34870751
Free PMC article.
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The small molecule activator S3969 stimulates the epithelial sodium channel by interacting with a specific binding pocket in the channel's β-subunit.
Sure F, Einsiedel J, Gmeiner P, Duchstein P, Zahn D, Korbmacher C, Ilyaskin AV.
Sure F, et al.
J Biol Chem. 2024 Apr;300(4):105785. doi: 10.1016/j.jbc.2024.105785. Epub 2024 Feb 23.
J Biol Chem. 2024.
PMID: 38401845
Free PMC article.
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