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A class of carbonic anhydrase IX/XII - selective carboxylate inhibitors.
Alhameed RA, Berrino E, Almarhoon Z, El-Faham A, Supuran CT. Alhameed RA, et al. Among authors: supuran ct. J Enzyme Inhib Med Chem. 2020 Dec;35(1):549-554. doi: 10.1080/14756366.2020.1715388. J Enzyme Inhib Med Chem. 2020. PMID: 31967484 Free PMC article.
Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells.
Petreni A, Bonardi A, Lomelino C, Osman SM, ALOthman ZA, Eldehna WM, El-Haggar R, McKenna R, Nocentini A, Supuran CT. Petreni A, et al. Among authors: supuran ct. Eur J Med Chem. 2020 Mar 15;190:112112. doi: 10.1016/j.ejmech.2020.112112. Epub 2020 Feb 3. Eur J Med Chem. 2020. PMID: 32044580
2,012 results