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USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice.
Dang F, Bai L, Dong J, Hu X, Wang J, Paulo JA, Xiong Y, Liang X, Sun Y, Chen Y, Guo M, Wang X, Huang Z, Inuzuka H, Chen L, Chu C, Liu J, Zhang T, Rezaeian AH, Liu J, Kaniskan HÜ, Zhong B, Zhang J, Letko M, Jin J, Lan K, Wei W. Dang F, et al. Among authors: sun y. Sci Transl Med. 2023 Dec 6;15(725):eadh7668. doi: 10.1126/scitranslmed.adh7668. Epub 2023 Dec 6. Sci Transl Med. 2023. PMID: 38055802
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy.
Xiao X, Shi J, He C, Bu X, Sun Y, Gao M, Xiang B, Xiong W, Dai P, Mao Q, Xing X, Yao Y, Yu H, Xu G, Li S, Ren Y, Chen B, Jiang C, Meng G, Lee YR, Wei W, Freeman GJ, Xie C, Zhang J. Xiao X, et al. Among authors: sun y. Nat Commun. 2023 May 19;14(1):2859. doi: 10.1038/s41467-023-38605-3. Nat Commun. 2023. PMID: 37208329 Free PMC article.
Targeting METTL3 reprograms the tumor microenvironment to improve cancer immunotherapy.
Yu H, Liu J, Bu X, Ma Z, Yao Y, Li J, Zhang T, Song W, Xiao X, Sun Y, Xiong W, Shi J, Dai P, Xiang B, Duan H, Yan X, Wu F, Zhang WC, Lin D, Hu H, Zhang H, Slack FJ, He HH, Freeman GJ, Wei W, Zhang J. Yu H, et al. Among authors: sun y. Cell Chem Biol. 2024 Apr 18;31(4):776-791.e7. doi: 10.1016/j.chembiol.2023.09.001. Epub 2023 Sep 25. Cell Chem Biol. 2024. PMID: 37751743
USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy.
Li H, Sun Y, Yao Y, Ke S, Zhang N, Xiong W, Shi J, He C, Xiao X, Yu H, Dai P, Xiang B, Xing X, Xu G, Song W, Song J, Zhang J. Li H, et al. Among authors: sun y. Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2315541121. doi: 10.1073/pnas.2315541121. Epub 2024 Apr 10. Proc Natl Acad Sci U S A. 2024. PMID: 38598341
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