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Blocking FSH induces thermogenic adipose tissue and reduces body fat.
Liu P, Ji Y, Yuen T, Rendina-Ruedy E, DeMambro VE, Dhawan S, Abu-Amer W, Izadmehr S, Zhou B, Shin AC, Latif R, Thangeswaran P, Gupta A, Li J, Shnayder V, Robinson ST, Yu YE, Zhang X, Yang F, Lu P, Zhou Y, Zhu LL, Oberlin DJ, Davies TF, Reagan MR, Brown A, Kumar TR, Epstein S, Iqbal J, Avadhani NG, New MI, Molina H, van Klinken JB, Guo EX, Buettner C, Haider S, Bian Z, Sun L, Rosen CJ, Zaidi M. Liu P, et al. Among authors: sun l. Nature. 2017 Jun 1;546(7656):107-112. doi: 10.1038/nature22342. Epub 2017 May 24. Nature. 2017. PMID: 28538730 Free PMC article.
Commentary-FSH and bone 2010: evolving evidence.
Iqbal J, Sun L, Zaidi M. Iqbal J, et al. Among authors: sun l. Eur J Endocrinol. 2010 Jul;163(1):173-6. doi: 10.1530/EJE-10-0397. Epub 2010 May 6. Eur J Endocrinol. 2010. PMID: 20448000
Blocking antibody to the β-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis.
Zhu LL, Blair H, Cao J, Yuen T, Latif R, Guo L, Tourkova IL, Li J, Davies TF, Sun L, Bian Z, Rosen C, Zallone A, New MI, Zaidi M. Zhu LL, et al. Among authors: sun l. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14574-9. doi: 10.1073/pnas.1212806109. Epub 2012 Aug 20. Proc Natl Acad Sci U S A. 2012. PMID: 22908268 Free PMC article.
Epitope-specific monoclonal antibodies to FSHβ increase bone mass.
Ji Y, Liu P, Yuen T, Haider S, He J, Romero R, Chen H, Bloch M, Kim SM, Lizneva D, Munshi L, Zhou C, Lu P, Iqbal J, Cheng Z, New MI, Hsueh AJ, Bian Z, Rosen CJ, Sun L, Zaidi M. Ji Y, et al. Among authors: sun l. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2192-2197. doi: 10.1073/pnas.1718144115. Epub 2018 Feb 12. Proc Natl Acad Sci U S A. 2018. PMID: 29440419 Free PMC article.
FSH, Bone Mass, Body Fat, and Biological Aging.
Zaidi M, Lizneva D, Kim SM, Sun L, Iqbal J, New MI, Rosen CJ, Yuen T. Zaidi M, et al. Among authors: sun l. Endocrinology. 2018 Oct 1;159(10):3503-3514. doi: 10.1210/en.2018-00601. Endocrinology. 2018. PMID: 30085049 Free PMC article.
FSH directly regulates bone mass.
Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, Bo W, Braun J, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M. Sun L, et al. Cell. 2006 Apr 21;125(2):247-60. doi: 10.1016/j.cell.2006.01.051. Cell. 2006. PMID: 16630814 Free article.
Regulation of FSH receptor promoter activation in the osteoclast.
Zaidi S, Zhu LL, Mali R, Iqbal J, Yang G, Zaidi M, Sun L. Zaidi S, et al. Among authors: sun l. Biochem Biophys Res Commun. 2007 Oct 5;361(4):910-5. doi: 10.1016/j.bbrc.2007.07.081. Epub 2007 Jul 24. Biochem Biophys Res Commun. 2007. PMID: 17681281
Proresorptive actions of FSH and bone loss.
Zaidi M, Blair HC, Iqbal J, Zhu LL, Kumar TR, Zallone A, Sun L. Zaidi M, et al. Among authors: sun l. Ann N Y Acad Sci. 2007 Nov;1116:376-82. doi: 10.1196/annals.1402.056. Ann N Y Acad Sci. 2007. PMID: 18083939 Review.
Coupling bone degradation to formation.
Iqbal J, Sun L, Zaidi M. Iqbal J, et al. Among authors: sun l. Nat Med. 2009 Jul;15(7):729-31. doi: 10.1038/nm0709-729. Nat Med. 2009. PMID: 19584858 No abstract available.
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