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Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD.
Sun H, Deng T, Zhang Y, Lin Y, Jiang Y, Jiang Y, Huang Y, Song S, Cui L, Li T, Xiong H, Lan M, Liu L, Li Y, Fang Q, Yu K, Jiang W, Zhou L, Que Y, Zhang T, Yuan Q, Cheng T, Zhang Z, Yu H, Zhang J, Luo W, Li S, Zheng Q, Gu Y, Xia N. Sun H, et al. Protein Cell. 2024 Feb 1;15(2):121-134. doi: 10.1093/procel/pwad040. Protein Cell. 2024. PMID: 37470320 Free PMC article.
Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating.
Xu L, Zheng Q, Zhu R, Yin Z, Yu H, Lin Y, Wu Y, He M, Huang Y, Jiang Y, Sun H, Zha Z, Yang H, Huang Q, Zhang D, Chen Z, Ye X, Han J, Yang L, Liu C, Que Y, Fang M, Gu Y, Zhang J, Luo W, Zhou ZH, Li S, Cheng T, Xia N. Xu L, et al. Among authors: sun h. Cell Host Microbe. 2021 Mar 10;29(3):448-462.e5. doi: 10.1016/j.chom.2021.01.001. Epub 2021 Feb 3. Cell Host Microbe. 2021. PMID: 33539764 Free PMC article.
Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants.
Li T, Xue W, Zheng Q, Song S, Yang C, Xiong H, Zhang S, Hong M, Zhang Y, Yu H, Zhang Y, Sun H, Huang Y, Deng T, Chi X, Li J, Wang S, Zhou L, Chen T, Wang Y, Cheng T, Zhang T, Yuan Q, Zhao Q, Zhang J, McLellan JS, Zhou ZH, Zhang Z, Li S, Gu Y, Xia N. Li T, et al. Among authors: sun h. Nat Commun. 2021 Sep 27;12(1):5652. doi: 10.1038/s41467-021-25997-3. Nat Commun. 2021. PMID: 34580306 Free PMC article.
Structures of pseudorabies virus capsids.
Wang G, Zha Z, Huang P, Sun H, Huang Y, He M, Chen T, Lin L, Chen Z, Kong Z, Que Y, Li T, Gu Y, Yu H, Zhang J, Zheng Q, Chen Y, Li S, Xia N. Wang G, et al. Among authors: sun h. Nat Commun. 2022 Mar 22;13(1):1533. doi: 10.1038/s41467-022-29250-3. Nat Commun. 2022. PMID: 35318331 Free PMC article.
Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron.
Wang S, Sun H, Zhang Y, Yuan L, Wang Y, Zhang T, Wang S, Zhang J, Yu H, Xiong H, Tang Z, Liu L, Huang Y, Chen X, Li T, Ying D, Liu C, Chen Z, Yuan Q, Zhang J, Cheng T, Li S, Guan Y, Zheng Q, Zheng Z, Xia N. Wang S, et al. Among authors: sun h. Cell Rep. 2022 May 24;39(8):110862. doi: 10.1016/j.celrep.2022.110862. Epub 2022 May 8. Cell Rep. 2022. PMID: 35594869 Free PMC article.
The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2.
Xiong H, Sun H, Wang S, Yuan L, Liu L, Zhu Y, Zhang J, Huang Y, Qi R, Jiang Y, Ma J, Zhou M, Ma Y, Fu R, Yan S, Yue M, Wu Y, Wei M, Wang Y, Li T, Wang Y, Zheng Z, Yu H, Cheng T, Li S, Yuan Q, Zhang J, Guan Y, Zheng Q, Zhang T, Xia N. Xiong H, et al. Among authors: sun h. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2204256119. doi: 10.1073/pnas.2204256119. Epub 2022 Aug 16. Proc Natl Acad Sci U S A. 2022. PMID: 35972965 Free PMC article.
Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail.
Zheng Q, Zhu R, Yin Z, Xu L, Sun H, Yu H, Wu Y, Jiang Y, Huang Q, Huang Y, Zhang D, Liu L, Yang H, He M, Zhou Z, Jiang Y, Chen Z, Zhao H, Que Y, Kong Z, Zhou L, Li T, Zhang J, Luo W, Gu Y, Cheng T, Li S, Xia N. Zheng Q, et al. Among authors: sun h. Cell Host Microbe. 2022 Sep 14;30(9):1279-1294.e6. doi: 10.1016/j.chom.2022.08.001. Epub 2022 Aug 23. Cell Host Microbe. 2022. PMID: 36002016 Free article.
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