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Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis.
Gao R, Peng X, Perry C, Sun H, Ntokou A, Ryu C, Gomez JL, Reeves BC, Walia A, Kaminski N, Neumark N, Ishikawa G, Black KE, Hariri LP, Moore MW, Gulati M, Homer RJ, Greif DM, Eltzschig HK, Herzog EL. Gao R, et al. Among authors: sun h. J Clin Invest. 2021 Jan 4;131(1):e136542. doi: 10.1172/JCI136542. J Clin Invest. 2021. PMID: 33393489 Free PMC article.
Fibroblast engraftment in the decellularized mouse lung occurs via a β1-integrin-dependent, FAK-dependent pathway that is mediated by ERK and opposed by AKT.
Sun H, Calle E, Chen X, Mathur A, Zhu Y, Mendez J, Zhao L, Niklason L, Peng X, Peng H, Herzog EL. Sun H, et al. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15;306(6):L463-75. doi: 10.1152/ajplung.00100.2013. Epub 2013 Dec 13. Am J Physiol Lung Cell Mol Physiol. 2014. PMID: 24337923 Free PMC article.
Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis.
Zhou Y, Peng H, Sun H, Peng X, Tang C, Gan Y, Chen X, Mathur A, Hu B, Slade MD, Montgomery RR, Shaw AC, Homer RJ, White ES, Lee CM, Moore MW, Gulati M, Lee CG, Elias JA, Herzog EL. Zhou Y, et al. Among authors: sun h. Sci Transl Med. 2014 Jun 11;6(240):240ra76. doi: 10.1126/scitranslmed.3007096. Sci Transl Med. 2014. PMID: 24920662 Free PMC article.
Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis.
Sun H, Zhu Y, Pan H, Chen X, Balestrini JL, Lam TT, Kanyo JE, Eichmann A, Gulati M, Fares WH, Bai H, Feghali-Bostwick CA, Gan Y, Peng X, Moore MW, White ES, Sava P, Gonzalez AL, Cheng Y, Niklason LE, Herzog EL. Sun H, et al. Arthritis Rheumatol. 2016 May;68(5):1251-61. doi: 10.1002/art.39575. Arthritis Rheumatol. 2016. PMID: 26749424 Free PMC article.
Matrix-driven Myosin II Mediates the Pro-fibrotic Fibroblast Phenotype.
Southern BD, Grove LM, Rahaman SO, Abraham S, Scheraga RG, Niese KA, Sun H, Herzog EL, Liu F, Tschumperlin DJ, Egelhoff TT, Rosenfeld SS, Olman MA. Southern BD, et al. Among authors: sun h. J Biol Chem. 2016 Mar 18;291(12):6083-95. doi: 10.1074/jbc.M115.712380. Epub 2016 Jan 13. J Biol Chem. 2016. PMID: 26763235 Free PMC article.
Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis.
Peng X, Moore M, Mathur A, Zhou Y, Sun H, Gan Y, Herazo-Maya JD, Kaminski N, Hu X, Pan H, Ryu C, Osafo-Addo A, Homer RJ, Feghali-Bostwick C, Fares WH, Gulati M, Hu B, Lee CG, Elias JA, Herzog EL. Peng X, et al. Among authors: sun h. FASEB J. 2016 Dec;30(12):4056-4070. doi: 10.1096/fj.201600373R. Epub 2016 Sep 8. FASEB J. 2016. PMID: 27609773 Free PMC article.
These data demonstrate the previously unrecognized observation that PLXNC1 deficiency permits Syt7-mediated macrophage migration and enhances mammalian lung fibrosis.-Peng, X., Moore, M., Mathur, A., Zhou, Y., Sun, H., Gan, Y., Herazo-Maya, J. D., Kaminski, N., Hu, …
These data demonstrate the previously unrecognized observation that PLXNC1 deficiency permits Syt7-mediated macrophage migration and enhance …
Extracellular Mitochondrial DNA Is Generated by Fibroblasts and Predicts Death in Idiopathic Pulmonary Fibrosis.
Ryu C, Sun H, Gulati M, Herazo-Maya JD, Chen Y, Osafo-Addo A, Brandsdorfer C, Winkler J, Blaul C, Faunce J, Pan H, Woolard T, Tzouvelekis A, Antin-Ozerkis DE, Puchalski JT, Slade M, Gonzalez AL, Bogenhagen DF, Kirillov V, Feghali-Bostwick C, Gibson K, Lindell K, Herzog RI, Dela Cruz CS, Mehal W, Kaminski N, Herzog EL, Trujillo G. Ryu C, et al. Among authors: sun h. Am J Respir Crit Care Med. 2017 Dec 15;196(12):1571-1581. doi: 10.1164/rccm.201612-2480OC. Am J Respir Crit Care Med. 2017. PMID: 28783377 Free PMC article.
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