Sun H - Search Results

1

Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms.

Zhou J, Jiang X, He S, Jiang H, Feng F, Liu W, Qu W, Sun H. Zhou J, et al. Among authors: sun h. J Med Chem. 2019 Oct 24;62(20):8881-8914. doi: 10.1021/acs.jmedchem.9b00017. Epub 2019 May 28. J Med Chem. 2019. PMID: 31082225 Review.

2

Garcinia xanthones as orally active antitumor agents.

Zhang X, Li X, Sun H, Wang X, Zhao L, Gao Y, Liu X, Zhang S, Wang Y, Yang Y, Zeng S, Guo Q, You Q. Zhang X, et al. Among authors: sun h. J Med Chem. 2013 Jan 10;56(1):276-92. doi: 10.1021/jm301593r. Epub 2012 Dec 31. J Med Chem. 2013. PMID: 23167526

3

Novel IKKβ inhibitors discovery based on the co-crystal structure by using binding-conformation-based and ligand-based method.

Huang JJ, Wu XW, Jia JM, Guo XK, Xue X, Jiang ZY, Zhang SL, Zhang XJ, Sun HP, You QD. Huang JJ, et al. Eur J Med Chem. 2013 May;63:269-78. doi: 10.1016/j.ejmech.2013.01.045. Epub 2013 Feb 17. Eur J Med Chem. 2013. PMID: 23501112

4

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors.

Guo X, Yang Q, Xu J, Zhang L, Chu H, Yu P, Zhu Y, Wei J, Chen W, Zhang Y, Zhang X, Sun H, Tang Y, You Q. Guo X, et al. Among authors: sun h. Bioorg Med Chem. 2013 Nov 1;21(21):6466-76. doi: 10.1016/j.bmc.2013.08.041. Epub 2013 Aug 31. Bioorg Med Chem. 2013. PMID: 24071446

5

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold.

Jia JM, Liu F, Xu XL, Guo XK, Jiang F, Cherfaoui B, Sun HP, You QD. Jia JM, et al. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1557-61. doi: 10.1016/j.bmcl.2014.01.070. Epub 2014 Feb 15. Bioorg Med Chem Lett. 2014. PMID: 24582477

6

Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening.

Sun HP, Jia JM, Jiang F, Xu XL, Liu F, Guo XK, Cherfaoui B, Huang HZ, Pan Y, You QD. Sun HP, et al. Eur J Med Chem. 2014 May 22;79:399-412. doi: 10.1016/j.ejmech.2014.03.061. Epub 2014 Mar 21. Eur J Med Chem. 2014. PMID: 24763261

7

Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I).

Guo X, Ma X, Yang Q, Xu J, Huang L, Jia J, Shan J, Liu L, Chen W, Chu H, Wei J, Zhang X, Sun H, Tang Y, You Q. Guo X, et al. Among authors: sun h. Eur J Med Chem. 2014 Jun 23;81:89-94. doi: 10.1016/j.ejmech.2014.03.075. Epub 2014 Mar 28. Eur J Med Chem. 2014. PMID: 24824064

8

Recent advances in the structure-based and ligand-based design of IKKβ inhibitors as anti-inflammation and anti-cancer agents.

Huang JJ, Chu HX, Jiang ZY, Zhang XJ, Sun HP, You QD. Huang JJ, et al. Curr Med Chem. 2014;21(34):3893-917. doi: 10.2174/0929867321666140815130205. Curr Med Chem. 2014. PMID: 25139725 Review.

9

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Xu LL, Zhu JF, Xu XL, Zhu J, Li L, Xi MY, Jiang ZY, Zhang MY, Liu F, Lu MC, Bao QC, Li Q, Zhang C, Wei JL, Zhang XJ, Zhang LS, You QD, Sun HP. Xu LL, et al. J Med Chem. 2015 Jul 23;58(14):5419-36. doi: 10.1021/acs.jmedchem.5b00170. Epub 2015 Jul 7. J Med Chem. 2015. PMID: 26111355

10

Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor.

Jiang ZY, Xu LL, Lu MC, Chen ZY, Yuan ZW, Xu XL, Guo XK, Zhang XJ, Sun HP, You QD. Jiang ZY, et al. J Med Chem. 2015 Aug 27;58(16):6410-21. doi: 10.1021/acs.jmedchem.5b00185. Epub 2015 Aug 14. J Med Chem. 2015. PMID: 26258437

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