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A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques.
Zhang XJ, Ji YX, Cheng X, Cheng Y, Yang H, Wang J, Zhao LP, Huang YP, Sun D, Xiang H, Shen LJ, Li PL, Ma JP, Tian RF, Yang J, Yao X, Xu H, Liao R, Xiao L, Zhang P, Zhang X, Zhao GN, Wang X, Hu ML, Tian S, Wan J, Cai J, Ma X, Xu Q, Wang Y, Touyz RM, Liu PP, Loomba R, She ZG, Li H. Zhang XJ, et al. Among authors: sun d. Sci Transl Med. 2021 Dec 15;13(624):eabg8116. doi: 10.1126/scitranslmed.abg8116. Epub 2021 Dec 15. Sci Transl Med. 2021. PMID: 34910548
Hepatocyte SH3RF2 Deficiency Is a Key Aggravator for NAFLD.
Yang X, Sun D, Xiang H, Wang S, Huang Y, Li L, Cheng X, Liu H, Hu F, Cheng Y, Ma T, Hu M, Tian H, Tian S, Zhou Y, Zhang P, Zhang XJ, Ji YX, Hu Y, Li H, She ZG. Yang X, et al. Among authors: sun d. Hepatology. 2021 Sep;74(3):1319-1338. doi: 10.1002/hep.31863. Epub 2021 Aug 30. Hepatology. 2021. PMID: 33894019
Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species.
Zhang XJ, Liu X, Hu M, Zhao GJ, Sun D, Cheng X, Xiang H, Huang YP, Tian RF, Shen LJ, Ma JP, Wang HP, Tian S, Gan S, Xu H, Liao R, Zou T, Ji YX, Zhang P, Cai J, Wang ZV, Meng G, Xu Q, Wang Y, Ma XL, Liu PP, Huang Z, Zhu L, She ZG, Zhang X, Bai L, Yang H, Lu Z, Li H. Zhang XJ, et al. Among authors: sun d. Cell Metab. 2021 Oct 5;33(10):2059-2075.e10. doi: 10.1016/j.cmet.2021.08.014. Epub 2021 Sep 17. Cell Metab. 2021. PMID: 34536344 Free article.
Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis.
Zhang XJ, She ZG, Wang J, Sun D, Shen LJ, Xiang H, Cheng X, Ji YX, Huang YP, Li PL, Yang X, Cheng Y, Ma JP, Wang HP, Hu Y, Hu F, Tian S, Tian H, Zhang P, Zhao GN, Wang L, Hu ML, Yang Q, Zhu LH, Cai J, Yang J, Zhang X, Ma X, Xu Q, Touyz RM, Liu PP, Loomba R, Wang Y, Li H. Zhang XJ, et al. Among authors: sun d. Sci Transl Med. 2021 Dec 15;13(624):eabg8117. doi: 10.1126/scitranslmed.abg8117. Epub 2021 Dec 15. Sci Transl Med. 2021. PMID: 34910546
The Role of the Intestinal Microbiota in Nonalcoholic Steatohepatitis.
Xiang H, Sun D, Liu X, She ZG, Chen Y. Xiang H, et al. Among authors: sun d. Front Endocrinol (Lausanne). 2022 Feb 8;13:812610. doi: 10.3389/fendo.2022.812610. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35211093 Free PMC article. Review.
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