Summerfield S - Search Results

1

Unbound Brain-to-Plasma Partition Coefficient, K_p,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development.

Loryan I, Reichel A, Feng B, Bundgaard C, Shaffer C, Kalvass C, Bednarczyk D, Morrison D, Lesuisse D, Hoppe E, Terstappen GC, Fischer H, Di L, Colclough N, Summerfield S, Buckley ST, Maurer TS, Fridén M. Loryan I, et al. Among authors: summerfield s. Pharm Res. 2022 Jul;39(7):1321-1341. doi: 10.1007/s11095-022-03246-6. Epub 2022 Apr 11. Pharm Res. 2022. PMID: 35411506 Free PMC article.

2

Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems.

Liu H, Dong K, Zhang W, Summerfield SG, Terstappen GC. Liu H, et al. Drug Discov Today. 2018 Jul;23(7):1357-1372. doi: 10.1016/j.drudis.2018.03.002. Epub 2018 Mar 13. Drug Discov Today. 2018. PMID: 29548981 Review.

3

Free Drug Theory - No Longer Just a Hypothesis?

Summerfield SG, Yates JWT, Fairman DA. Summerfield SG, et al. Pharm Res. 2022 Feb;39(2):213-222. doi: 10.1007/s11095-022-03172-7. Epub 2022 Feb 2. Pharm Res. 2022. PMID: 35112229

4

Assessment of the blood-brain barrier in CNS drug discovery.

Jeffrey P, Summerfield S. Jeffrey P, et al. Among authors: summerfield s. Neurobiol Dis. 2010 Jan;37(1):33-7. doi: 10.1016/j.nbd.2009.07.033. Epub 2009 Aug 5. Neurobiol Dis. 2010. PMID: 19664709 Review.

5

Integrating in Silico and in Vitro Approaches To Predict Drug Accessibility to the Central Nervous System.

Zhang YY, Liu H, Summerfield SG, Luscombe CN, Sahi J. Zhang YY, et al. Mol Pharm. 2016 May 2;13(5):1540-50. doi: 10.1021/acs.molpharmaceut.6b00031. Epub 2016 Apr 4. Mol Pharm. 2016. PMID: 27015243

6

Drug Distribution into Peripheral Nerve.

Liu H, Chen Y, Huang L, Sun X, Fu T, Wu S, Zhu X, Zhen W, Liu J, Lu G, Cai W, Yang T, Zhang W, Yu X, Wan Z, Wang J, Summerfield SG, Dong K, Terstappen GC. Liu H, et al. Among authors: summerfield sg. J Pharmacol Exp Ther. 2018 May;365(2):336-345. doi: 10.1124/jpet.117.245613. Epub 2018 Mar 6. J Pharmacol Exp Ther. 2018. PMID: 29511033

7

Examining the Uptake of Central Nervous System Drugs and Candidates across the Blood-Brain Barrier.

Summerfield SG, Zhang Y, Liu H. Summerfield SG, et al. J Pharmacol Exp Ther. 2016 Aug;358(2):294-305. doi: 10.1124/jpet.116.232447. Epub 2016 May 18. J Pharmacol Exp Ther. 2016. PMID: 27194478

8

In vitro, in vivo and in silico models of drug distribution into the brain.

Summerfield SG, Dong KC. Summerfield SG, et al. J Pharmacokinet Pharmacodyn. 2013 Jun;40(3):301-14. doi: 10.1007/s10928-013-9303-7. Epub 2013 Feb 13. J Pharmacokinet Pharmacodyn. 2013. PMID: 23404394 Review.

9

Toward an improved prediction of human in vivo brain penetration.

Summerfield SG, Lucas AJ, Porter RA, Jeffrey P, Gunn RN, Read KR, Stevens AJ, Metcalf AC, Osuna MC, Kilford PJ, Passchier J, Ruffo AD. Summerfield SG, et al. Xenobiotica. 2008 Dec;38(12):1518-35. doi: 10.1080/00498250802499459. Xenobiotica. 2008. PMID: 18979396

10

Rapid Bioavailability and Disposition protocol: A novel higher throughput approach to assess pharmacokinetics and steady-state brain distribution with reduced animal usage.

Fu T, Gao R, Scott-Stevens P, Chen Y, Zhang C, Wang J, Summerfield S, Liu H, Sahi J. Fu T, et al. Among authors: summerfield s. Eur J Pharm Sci. 2018 Sep 15;122:13-21. doi: 10.1016/j.ejps.2018.05.027. Epub 2018 May 29. Eur J Pharm Sci. 2018. PMID: 29857045

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