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Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance.
Socodato R, Almeida TO, Portugal CC, Santos ECS, Tedim-Moreira J, Galvão-Ferreira J, Canedo T, Baptista FI, Magalhães A, Ambrósio AF, Brakebusch C, Rubinstein B, Moreira IS, Summavielle T, Pinto IM, Relvas JB. Socodato R, et al. Among authors: summavielle t. Cell Rep. 2023 Dec 26;42(12):113447. doi: 10.1016/j.celrep.2023.113447. Epub 2023 Nov 18. Cell Rep. 2023. PMID: 37980559 Free article.
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration.
Socodato R, Portugal CC, Canedo T, Rodrigues A, Almeida TO, Henriques JF, Vaz SH, Magalhães J, Silva CM, Baptista FI, Alves RL, Coelho-Santos V, Silva AP, Paes-de-Carvalho R, Magalhães A, Brakebusch C, Sebastião AM, Summavielle T, Ambrósio AF, Relvas JB. Socodato R, et al. Among authors: summavielle t. Cell Rep. 2020 Jun 23;31(12):107796. doi: 10.1016/j.celrep.2020.107796. Cell Rep. 2020. PMID: 32579923 Free article.
Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine.
Canedo T, Portugal CC, Socodato R, Almeida TO, Terceiro AF, Bravo J, Silva AI, Magalhães JD, Guerra-Gomes S, Oliveira JF, Sousa N, Magalhães A, Relvas JB, Summavielle T. Canedo T, et al. Among authors: summavielle t. Neuropsychopharmacology. 2021 Dec;46(13):2358-2370. doi: 10.1038/s41386-021-01139-7. Epub 2021 Aug 16. Neuropsychopharmacology. 2021. PMID: 34400780 Free PMC article.
Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells.
Coelho-Santos V, Socodato R, Portugal C, Leitão RA, Rito M, Barbosa M, Couraud PO, Romero IA, Weksler B, Minshall RD, Fontes-Ribeiro C, Summavielle T, Relvas JB, Silva AP. Coelho-Santos V, et al. Among authors: summavielle t. Cell Mol Life Sci. 2016 Dec;73(24):4701-4716. doi: 10.1007/s00018-016-2301-3. Epub 2016 Jul 4. Cell Mol Life Sci. 2016. PMID: 27376435
Profiling Microglia in a Mouse Model of Machado-Joseph Disease.
Campos AB, Duarte-Silva S, Fernandes B, das Neves SP, Marques F, Teixeira-Castro A, Neves-Carvalho A, Monteiro-Fernandes D, Portugal CC, Socodato R, Summavielle T, Ambrósio AF, Relvas JB, Maciel P. Campos AB, et al. Among authors: summavielle t. Biomedicines. 2022 Jan 23;10(2):237. doi: 10.3390/biomedicines10020237. Biomedicines. 2022. PMID: 35203447 Free PMC article.
Expression of Rac1 alternative 3' UTRs is a cell specific mechanism with a function in dendrite outgrowth in cortical neurons.
Braz SO, Cruz A, Lobo A, Bravo J, Moreira-Ribeiro J, Pereira-Castro I, Freitas J, Relvas JB, Summavielle T, Moreira A. Braz SO, et al. Among authors: summavielle t. Biochim Biophys Acta Gene Regul Mech. 2017 Jun;1860(6):685-694. doi: 10.1016/j.bbagrm.2017.03.002. Epub 2017 Mar 6. Biochim Biophys Acta Gene Regul Mech. 2017. PMID: 28274785
49 results