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Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice.
Al-Habsi M, Chamoto K, Matsumoto K, Nomura N, Zhang B, Sugiura Y, Sonomura K, Maharani A, Nakajima Y, Wu Y, Nomura Y, Menzies R, Tajima M, Kitaoka K, Haku Y, Delghandi S, Yurimoto K, Matsuda F, Iwata S, Ogura T, Fagarasan S, Honjo T. Al-Habsi M, et al. Among authors: sugiura y. Science. 2022 Oct 28;378(6618):eabj3510. doi: 10.1126/science.abj3510. Epub 2022 Oct 28. Science. 2022. PMID: 36302005
Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior.
Miyajima M, Zhang B, Sugiura Y, Sonomura K, Guerrini MM, Tsutsui Y, Maruya M, Vogelzang A, Chamoto K, Honda K, Hikida T, Ito S, Qin H, Sanuki R, Suzuki K, Furukawa T, Ishihama Y, Matsuda F, Suematsu M, Honjo T, Fagarasan S. Miyajima M, et al. Among authors: sugiura y. Nat Immunol. 2017 Dec;18(12):1342-1352. doi: 10.1038/ni.3867. Epub 2017 Oct 23. Nat Immunol. 2017. PMID: 29058703
B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity.
Zhang B, Vogelzang A, Miyajima M, Sugiura Y, Wu Y, Chamoto K, Nakano R, Hatae R, Menzies RJ, Sonomura K, Hojo N, Ogawa T, Kobayashi W, Tsutsui Y, Yamamoto S, Maruya M, Narushima S, Suzuki K, Sugiya H, Murakami K, Hashimoto M, Ueno H, Kobayashi T, Ito K, Hirano T, Shiroguchi K, Matsuda F, Suematsu M, Honjo T, Fagarasan S. Zhang B, et al. Among authors: sugiura y. Nature. 2021 Nov;599(7885):471-476. doi: 10.1038/s41586-021-04082-1. Epub 2021 Nov 3. Nature. 2021. PMID: 34732892 Free PMC article.
Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders.
Johmura Y, Yamanaka T, Omori S, Wang TW, Sugiura Y, Matsumoto M, Suzuki N, Kumamoto S, Yamaguchi K, Hatakeyama S, Takami T, Yamaguchi R, Shimizu E, Ikeda K, Okahashi N, Mikawa R, Suematsu M, Arita M, Sugimoto M, Nakayama KI, Furukawa Y, Imoto S, Nakanishi M. Johmura Y, et al. Among authors: sugiura y. Science. 2021 Jan 15;371(6526):265-270. doi: 10.1126/science.abb5916. Science. 2021. PMID: 33446552
Pharmacological intervention of cholesterol sulfate-mediated T cell exclusion promotes antitumor immunity.
Tatsuguchi T, Uruno T, Sugiura Y, Oisaki K, Takaya D, Sakata D, Izumi Y, Togo T, Hattori Y, Kunimura K, Sakurai T, Honma T, Bamba T, Nakamura M, Kanai M, Suematsu M, Fukui Y. Tatsuguchi T, et al. Among authors: sugiura y. Biochem Biophys Res Commun. 2022 Jun 18;609:183-188. doi: 10.1016/j.bbrc.2022.04.035. Epub 2022 Apr 10. Biochem Biophys Res Commun. 2022. PMID: 35452959 Free article.
Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.
Kabe Y, Nakane T, Koike I, Yamamoto T, Sugiura Y, Harada E, Sugase K, Shimamura T, Ohmura M, Muraoka K, Yamamoto A, Uchida T, Iwata S, Yamaguchi Y, Krayukhina E, Noda M, Handa H, Ishimori K, Uchiyama S, Kobayashi T, Suematsu M. Kabe Y, et al. Among authors: sugiura y. Nat Commun. 2016 Mar 18;7:11030. doi: 10.1038/ncomms11030. Nat Commun. 2016. PMID: 26988023 Free PMC article.
Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells.
Tatsuguchi T, Uruno T, Sugiura Y, Sakata D, Izumi Y, Sakurai T, Hattori Y, Oki E, Kubota N, Nishimoto K, Oyama M, Kunimura K, Ohki T, Bamba T, Tahara H, Sakamoto M, Nakamura M, Suematsu M, Fukui Y. Tatsuguchi T, et al. Among authors: sugiura y. Int Immunol. 2022 Apr 20;34(5):277-289. doi: 10.1093/intimm/dxac002. Int Immunol. 2022. PMID: 35094065 Free PMC article.
Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress.
Nishio K, Kawarasaki T, Sugiura Y, Matsumoto S, Konoshima A, Takano Y, Hayashi M, Okumura F, Kamura T, Mizushima T, Nakatsukasa K. Nishio K, et al. Among authors: sugiura y. Sci Adv. 2023 Apr 14;9(15):eadf1956. doi: 10.1126/sciadv.adf1956. Epub 2023 Apr 14. Sci Adv. 2023. PMID: 37058555 Free PMC article.
A defined commensal consortium elicits CD8 T cells and anti-cancer immunity.
Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y, Narushima S, Vlamakis H, Motoo I, Sugita K, Shiota A, Takeshita K, Yasuma-Mitobe K, Riethmacher D, Kaisho T, Norman JM, Mucida D, Suematsu M, Yaguchi T, Bucci V, Inoue T, Kawakami Y, Olle B, Roberts B, Hattori M, Xavier RJ, Atarashi K, Honda K. Tanoue T, et al. Among authors: sugiura y. Nature. 2019 Jan;565(7741):600-605. doi: 10.1038/s41586-019-0878-z. Epub 2019 Jan 23. Nature. 2019. PMID: 30675064
1,271 results