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In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.
Shima F, Yoshikawa Y, Ye M, Araki M, Matsumoto S, Liao J, Hu L, Sugimoto T, Ijiri Y, Takeda A, Nishiyama Y, Sato C, Muraoka S, Tamura A, Osoda T, Tsuda K, Miyakawa T, Fukunishi H, Shimada J, Kumasaka T, Yamamoto M, Kataoka T. Shima F, et al. Among authors: sugimoto t. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7. doi: 10.1073/pnas.1217730110. Epub 2013 Apr 29. Proc Natl Acad Sci U S A. 2013. PMID: 23630290 Free PMC article.
Structural basis for conformational dynamics of GTP-bound Ras protein.
Shima F, Ijiri Y, Muraoka S, Liao J, Ye M, Araki M, Matsumoto K, Yamamoto N, Sugimoto T, Yoshikawa Y, Kumasaka T, Yamamoto M, Tamura A, Kataoka T. Shima F, et al. Among authors: sugimoto t. J Biol Chem. 2010 Jul 16;285(29):22696-705. doi: 10.1074/jbc.M110.125161. Epub 2010 May 17. J Biol Chem. 2010. PMID: 20479006 Free PMC article.
Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics.
Liao J, Shima F, Araki M, Ye M, Muraoka S, Sugimoto T, Kawamura M, Yamamoto N, Tamura A, Kataoka T. Liao J, et al. Among authors: sugimoto t. Biochem Biophys Res Commun. 2008 May 2;369(2):327-32. doi: 10.1016/j.bbrc.2008.01.169. Epub 2008 Feb 20. Biochem Biophys Res Commun. 2008. PMID: 18291096
3,507 results