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First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease.
J Med Chem. 2024 Jan 25;67(2):1580-1610. doi: 10.1021/acs.jmedchem.3c02148. Epub 2024 Jan 8.
J Med Chem. 2024.
PMID: 38190615
Free PMC article.
Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer's disease for potent serotonin 5-HT6R agents.
Sudoł-Tałaj S, Kucwaj-Brysz K, Podlewska S, Kurczab R, Satała G, Mordyl B, Głuch-Lutwin M, Wilczyńska-Zawal N, Jastrzębska-Więsek M, Czarnota-Łydka K, Kurowska K, Kubacka M, Żesławska E, Nitek W, Olejarz-Maciej A, Doroz-Płonka A, Partyka A, Latacz G, Wesołowska A, Handzlik J.
Sudoł-Tałaj S, et al.
Eur J Med Chem. 2023 Nov 15;260:115756. doi: 10.1016/j.ejmech.2023.115756. Epub 2023 Aug 24.
Eur J Med Chem. 2023.
PMID: 37657272
Free article.
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Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease.
Czarnota-Łydka K, Sudoł-Tałaj S, Kucwaj-Brysz K, Kurczab R, Satała G, de Candia M, Samarelli F, Altomare CD, Carocci A, Barbarossa A, Żesławska E, Głuch-Lutwin M, Mordyl B, Kubacka M, Wilczyńska-Zawal N, Jastrzębska-Więsek M, Partyka A, Khan N, Więcek M, Nitek W, Honkisz-Orzechowska E, Latacz G, Wesołowska A, Carrieri A, Handzlik J.
Czarnota-Łydka K, et al. Among authors: sudol talaj s.
Eur J Med Chem. 2023 Nov 5;259:115695. doi: 10.1016/j.ejmech.2023.115695. Epub 2023 Jul 30.
Eur J Med Chem. 2023.
PMID: 37567058
Free article.
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Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease.
Godyń J, Zaręba P, Stary D, Kaleta M, Kuder KJ, Latacz G, Mogilski S, Reiner-Link D, Frank A, Doroz-Płonka A, Olejarz-Maciej A, Sudoł-Tałaj S, Nolte T, Handzlik J, Stark H, Więckowska A, Malawska B, Kieć-Kononowicz K, Łażewska D, Bajda M.
Godyń J, et al. Among authors: sudol talaj s.
Molecules. 2022 Dec 28;28(1):238. doi: 10.3390/molecules28010238.
Molecules. 2022.
PMID: 36615435
Free PMC article.
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An exit beyond the pharmacophore model for 5-HT6R agents - a new strategy to gain dual 5-HT6/5-HT2A action for triazine derivatives with procognitive potential.
Kucwaj-Brysz K, Ali W, Kurczab R, Sudoł-Tałaj S, Wilczyńska-Zawal N, Jastrzębska-Więsek M, Satała G, Mordyl B, Żesławska E, Agnieszka-Olejarz-Maciej, Czarnota K, Latacz G, Partyka A, Wesołowska A, Nitek W, Handzlik J.
Kucwaj-Brysz K, et al. Among authors: sudol talaj s.
Bioorg Chem. 2022 Apr;121:105695. doi: 10.1016/j.bioorg.2022.105695. Epub 2022 Feb 19.
Bioorg Chem. 2022.
PMID: 35228010
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