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α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
Ghanem SS, Majbour NK, Vaikath NN, Ardah MT, Erskine D, Jensen NM, Fayyad M, Sudhakaran IP, Vasili E, Melachroinou K, Abdi IY, Poggiolini I, Santos P, Dorn A, Carloni P, Vekrellis K, Attems J, McKeith I, Outeiro TF, Jensen PH, El-Agnaf OMA. Ghanem SS, et al. Among authors: sudhakaran ip. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2109617119. doi: 10.1073/pnas.2109617119. Epub 2022 Mar 30. Proc Natl Acad Sci U S A. 2022. PMID: 35353605 Free PMC article.
Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.
Hmila I, Vaikath NN, Majbour NK, Erskine D, Sudhakaran IP, Gupta V, Ghanem SS, Islam Z, Emara MM, Abdesselem HB, Kolatkar PR, Achappa DK, Vinardell T, El-Agnaf OMA. Hmila I, et al. Among authors: sudhakaran ip. FEBS J. 2022 Aug;289(15):4657-4673. doi: 10.1111/febs.16376. Epub 2022 Feb 25. FEBS J. 2022. PMID: 35090199 Free PMC article.
Investigating the presence of doubly phosphorylated α-synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases.
Fayyad M, Erskine D, Majbour NK, Vaikath NN, Ghanem SS, Sudhakaran IP, Abdesselem H, Lamprokostopoulou A, Vekrellis K, Morris CM, Attems J, El-Agnaf OMA. Fayyad M, et al. Among authors: sudhakaran ip. Brain Pathol. 2020 Jul;30(4):831-843. doi: 10.1111/bpa.12845. Epub 2020 May 6. Brain Pathol. 2020. PMID: 32324926 Free PMC article.
RNP-Granule Assembly via Ataxin-2 Disordered Domains Is Required for Long-Term Memory and Neurodegeneration.
Bakthavachalu B, Huelsmeier J, Sudhakaran IP, Hillebrand J, Singh A, Petrauskas A, Thiagarajan D, Sankaranarayanan M, Mizoue L, Anderson EN, Pandey UB, Ross E, VijayRaghavan K, Parker R, Ramaswami M. Bakthavachalu B, et al. Among authors: sudhakaran ip. Neuron. 2018 May 16;98(4):754-766.e4. doi: 10.1016/j.neuron.2018.04.032. Neuron. 2018. PMID: 29772202 Free article.
Dysregulation of mRNA Localization and Translation in Genetic Disease.
Wang ET, Taliaferro JM, Lee JA, Sudhakaran IP, Rossoll W, Gross C, Moss KR, Bassell GJ. Wang ET, et al. Among authors: sudhakaran ip. J Neurosci. 2016 Nov 9;36(45):11418-11426. doi: 10.1523/JNEUROSCI.2352-16.2016. J Neurosci. 2016. PMID: 27911744 Free PMC article. Review.
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