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Reverse pharmacology of Nimbin-N2 attenuates alcoholic liver injury and promotes the hepatoprotective dual role of improving lipid metabolism and downregulating the levels of inflammatory cytokines in zebrafish larval model.
Sudhakaran G, Prathap P, Guru A, Haridevamuthu B, Murugan R, Almutairi BO, Almutairi MH, Juliet A, Gopinath P, Arockiaraj J. Sudhakaran G, et al. Mol Cell Biochem. 2022 Oct;477(10):2387-2401. doi: 10.1007/s11010-022-04448-7. Epub 2022 May 16. Mol Cell Biochem. 2022. PMID: 35575874
Deacetylated nimbin analog N2 fortifies alloxan-induced pancreatic β-cell damage in insulin-resistant zebrafish larvae by upregulating phosphoenolpyruvate carboxykinase (PEPCK) and insulin levels.
Sudhakaran G, Rajesh R, Guru A, Haridevamuthu B, Murugan R, Bhuvanesh N, Wadaan MA, Mahboob S, Juliet A, Gopinath P, Arockiaraj J. Sudhakaran G, et al. Toxicol Appl Pharmacol. 2022 Nov 1;454:116229. doi: 10.1016/j.taap.2022.116229. Epub 2022 Sep 8. Toxicol Appl Pharmacol. 2022. PMID: 36089001
30 results