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Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue states.
Al-Dalahmah O, Argenziano MG, Kannan A, Mahajan A, Furnari J, Paryani F, Boyett D, Save A, Humala N, Khan F, Li J, Lu H, Sun Y, Tuddenham JF, Goldberg AR, Dovas A, Banu MA, Sudhakar T, Bush E, Lassman AB, McKhann GM, Gill BJA, Youngerman B, Sisti MB, Bruce JN, Sims PA, Menon V, Canoll P. Al-Dalahmah O, et al. Among authors: sudhakar t. Nat Commun. 2023 May 4;14(1):2586. doi: 10.1038/s41467-023-38186-1. Nat Commun. 2023. PMID: 37142563 Free PMC article.
Cerebral Hyperperfusion Syndrome by the Numbers: Transient Focal Neurological Deficit, Imaging-Proven Focal Hyperperfusion, and High Graft Flow Rate Following Superficial Temporal Artery-Middle Cerebral Artery bypass in a Patient With Symptomatic Carotid Occlusion-Case Report.
Rahme R, Sudhakar TD, Alimi M, White TG, Ortiz RA, Langer DJ. Rahme R, et al. Oper Neurosurg (Hagerstown). 2018 Dec 1;15(6):E94-E99. doi: 10.1093/ons/opy010. Oper Neurosurg (Hagerstown). 2018. PMID: 29514319
BOLD asynchrony elucidates tumor burden in IDH-mutated gliomas.
Petridis PD, Horenstein CI, Pereira B, Wu PB, Samanamud J, Marie T, Boyett D, Sudhakar TD, Sheth SA, McKhann GM, Sisti MB, Bruce JN, Canoll P, Grinband J. Petridis PD, et al. Among authors: sudhakar td. Neuro Oncol. 2022 Jan 5;24(1):78-87. doi: 10.1093/neuonc/noab154. Neuro Oncol. 2022. PMID: 34214170 Free PMC article.
Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial.
Spinazzi EF, Argenziano MG, Upadhyayula PS, Banu MA, Neira JA, Higgins DMO, Wu PB, Pereira B, Mahajan A, Humala N, Al-Dalahmah O, Zhao W, Save AV, Gill BJA, Boyett DM, Marie T, Furnari JL, Sudhakar TD, Stopka SA, Regan MS, Catania V, Good L, Zacharoulis S, Behl M, Petridis P, Jambawalikar S, Mintz A, Lignelli A, Agar NYR, Sims PA, Welch MR, Lassman AB, Iwamoto FM, D'Amico RS, Grinband J, Canoll P, Bruce JN. Spinazzi EF, et al. Among authors: sudhakar td. Lancet Oncol. 2022 Nov;23(11):1409-1418. doi: 10.1016/S1470-2045(22)00599-X. Epub 2022 Oct 13. Lancet Oncol. 2022. PMID: 36243020 Free PMC article. Clinical Trial.
Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism.
Upadhyayula PS, Higgins DM, Mela A, Banu M, Dovas A, Zandkarimi F, Patel P, Mahajan A, Humala N, Nguyen TTT, Chaudhary KR, Liao L, Argenziano M, Sudhakar T, Sperring CP, Shapiro BL, Ahmed ER, Kinslow C, Ye LF, Siegelin MD, Cheng S, Soni R, Bruce JN, Stockwell BR, Canoll P. Upadhyayula PS, et al. Among authors: sudhakar t. Nat Commun. 2023 Mar 2;14(1):1187. doi: 10.1038/s41467-023-36630-w. Nat Commun. 2023. PMID: 36864031 Free PMC article.
Glioma-Induced Alterations in Excitatory Neurons are Reversed by mTOR Inhibition.
Goldberg AR, Dovas A, Torres D, Sharma SD, Mela A, Merricks EM, Olabarria M, Shokooh LA, Zhao HT, Kotidis C, Calvaresi P, Viswanathan A, Banu MA, Razavilar A, Sudhakar TD, Saxena A, Chokran C, Humala N, Mahajan A, Xu W, Metz JB, Chen C, Bushong EA, Boassa D, Ellisman MH, Hillman EMC, McKhann GM 2nd, Gill BJA, Rosenfeld SS, Schevon CA, Bruce JN, Sims PA, Peterka DS, Canoll P. Goldberg AR, et al. Among authors: sudhakar td. bioRxiv [Preprint]. 2024 Jan 21:2024.01.10.575092. doi: 10.1101/2024.01.10.575092. bioRxiv. 2024. PMID: 38293120 Free PMC article. Preprint.
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