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A Quantitative Systems Pharmacology Model Describing the Cellular Kinetic-Pharmacodynamic Relationship for a Live Biotherapeutic Product to Support Microbiome Drug Development.
Renardy M, Prokopienko AJ, Maxwell JR, Flusberg DA, Makaryan S, Selimkhanov J, Vakilynejad M, Subramanian K, Wille L. Renardy M, et al. Among authors: subramanian k. Clin Pharmacol Ther. 2023 Sep;114(3):633-643. doi: 10.1002/cpt.2952. Epub 2023 Jun 2. Clin Pharmacol Ther. 2023. PMID: 37218407
Quantitative modeling predicts competitive advantages of a next generation anti-NKG2A monoclonal antibody over monalizumab for the treatment of cancer.
Spinosa P, Musial-Siwek M, Presler M, Betts A, Rosentrater E, Villali J, Wille L, Zhao Y, McCaughtry T, Subramanian K, Liu H. Spinosa P, et al. Among authors: subramanian k. CPT Pharmacometrics Syst Pharmacol. 2021 Mar;10(3):220-229. doi: 10.1002/psp4.12592. Epub 2021 Feb 13. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 33501768 Free PMC article.
Two heads are better than one: current landscape of integrating QSP and machine learning : An ISoP QSP SIG white paper by the working group on the integration of quantitative systems pharmacology and machine learning.
Zhang T, Androulakis IP, Bonate P, Cheng L, Helikar T, Parikh J, Rackauckas C, Subramanian K, Cho CR; Working Group. Zhang T, et al. Among authors: subramanian k. J Pharmacokinet Pharmacodyn. 2022 Feb;49(1):5-18. doi: 10.1007/s10928-022-09805-z. Epub 2022 Feb 1. J Pharmacokinet Pharmacodyn. 2022. PMID: 35103884 Free PMC article. Review.
ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1-Directed 4-1BB Activation.
Yuwen H, Wang H, Li T, Ren Y, Zhang YK, Chen P, Sun A, Bian G, Li B, Flowers D, Presler M, Subramanian K, Xue J, Wang J, Lynch K, Mei J, He X, Shan B, Hou B. Yuwen H, et al. Among authors: subramanian k. Cancer Res. 2024 May 15;84(10):1680-1698. doi: 10.1158/0008-5472.CAN-23-2701. Cancer Res. 2024. PMID: 38501978 Free PMC article.
677 results