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Vitamin C epigenetically controls osteogenesis and bone mineralization.
Thaler R, Khani F, Sturmlechner I, Dehghani SS, Denbeigh JM, Zhou X, Pichurin O, Dudakovic A, Jerez SS, Zhong J, Lee JH, Natarajan R, Kalajzic I, Jiang YH, Deyle DR, Paschalis EP, Misof BM, Ordog T, van Wijnen AJ. Thaler R, et al. Among authors: sturmlechner i. Nat Commun. 2022 Oct 6;13(1):5883. doi: 10.1038/s41467-022-32915-8. Nat Commun. 2022. PMID: 36202795 Free PMC article.
Anabolic and Antiresorptive Modulation of Bone Homeostasis by the Epigenetic Modulator Sulforaphane, a Naturally Occurring Isothiocyanate.
Thaler R, Maurizi A, Roschger P, Sturmlechner I, Khani F, Spitzer S, Rumpler M, Zwerina J, Karlic H, Dudakovic A, Klaushofer K, Teti A, Rucci N, Varga F, van Wijnen AJ. Thaler R, et al. Among authors: sturmlechner i. J Biol Chem. 2016 Mar 25;291(13):6754-71. doi: 10.1074/jbc.M115.678235. Epub 2016 Jan 12. J Biol Chem. 2016. PMID: 26757819 Free PMC article.
p21 produces a bioactive secretome that places stressed cells under immunosurveillance.
Sturmlechner I, Zhang C, Sine CC, van Deursen EJ, Jeganathan KB, Hamada N, Grasic J, Friedman D, Stutchman JT, Can I, Hamada M, Lim DY, Lee JH, Ordog T, Laberge RM, Shapiro V, Baker DJ, Li H, van Deursen JM. Sturmlechner I, et al. Science. 2021 Oct 29;374(6567):eabb3420. doi: 10.1126/science.abb3420. Epub 2021 Oct 29. Science. 2021. PMID: 34709885 Free PMC article.
FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer.
Limzerwala JF, Jeganathan KB, Kloeber JA, Davies BA, Zhang C, Sturmlechner I, Zhong J, Fierro Velasco R, Fields AP, Yuan Y, Baker DJ, Zhou D, Li H, Katzmann DJ, van Deursen JM. Limzerwala JF, et al. Among authors: sturmlechner i. Nat Cancer. 2020 Oct;1(10):1010-1024. doi: 10.1038/s43018-020-00116-1. Epub 2020 Oct 12. Nat Cancer. 2020. PMID: 34841254 Free PMC article.
Cellular senescence in renal ageing and disease.
Sturmlechner I, Durik M, Sieben CJ, Baker DJ, van Deursen JM. Sturmlechner I, et al. Nat Rev Nephrol. 2017 Feb;13(2):77-89. doi: 10.1038/nrneph.2016.183. Epub 2016 Dec 28. Nat Rev Nephrol. 2017. PMID: 28029153 Review.
Two-Step Senescence-Focused Cancer Therapies.
Sieben CJ, Sturmlechner I, van de Sluis B, van Deursen JM. Sieben CJ, et al. Among authors: sturmlechner i. Trends Cell Biol. 2018 Sep;28(9):723-737. doi: 10.1016/j.tcb.2018.04.006. Epub 2018 May 17. Trends Cell Biol. 2018. PMID: 29776716 Free PMC article. Review.
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