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Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.
Okaniwa M, Shibata A, Ochida A, Akao Y, White KL, Shackleford DM, Duffy S, Lucantoni L, Dey S, Striepen J, Yeo T, Mok S, Aguiar ACC, Sturm A, Crespo B, Sanz LM, Churchyard A, Baum J, Pereira DB, Guido RVC, Dechering KJ, Wittlin S, Uhlemann AC, Fidock DA, Niles JC, Avery VM, Charman SA, Laleu B. Okaniwa M, et al. Among authors: sturm a. ACS Infect Dis. 2021 Jun 11;7(6):1680-1689. doi: 10.1021/acsinfecdis.1c00020. Epub 2021 Apr 30. ACS Infect Dis. 2021. PMID: 33929818 Free PMC article.
Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials.
Laleu B, Akao Y, Ochida A, Duffy S, Lucantoni L, Shackleford DM, Chen G, Katneni K, Chiu FCK, White KL, Chen X, Sturm A, Dechering KJ, Crespo B, Sanz LM, Wang B, Wittlin S, Charman SA, Avery VM, Cho N, Kamaura M. Laleu B, et al. Among authors: sturm a. J Med Chem. 2021 Sep 9;64(17):12582-12602. doi: 10.1021/acs.jmedchem.1c00441. Epub 2021 Aug 26. J Med Chem. 2021. PMID: 34437804 Free article.
Generation of a Genetically Modified Chimeric Plasmodium falciparum Parasite Expressing Plasmodium vivax Circumsporozoite Protein for Malaria Vaccine Development.
Miyazaki Y, Marin-Mogollon C, Imai T, Mendes AM, van der Laak R, Sturm A, Geurten FJA, Miyazaki S, Chevalley-Maurel S, Ramesar J, Kolli SK, Kroeze H, van Schuijlenburg R, Salman AM, Wilder BK, Reyes-Sandoval A, Dechering KJ, Prudêncio M, Janse CJ, Khan SM, Franke-Fayard B. Miyazaki Y, et al. Among authors: sturm a. Front Cell Infect Microbiol. 2020 Dec 17;10:591046. doi: 10.3389/fcimb.2020.591046. eCollection 2020. Front Cell Infect Microbiol. 2020. PMID: 33392104 Free PMC article.
Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases.
Miglianico M, Eldering M, Slater H, Ferguson N, Ambrose P, Lees RS, Koolen KMJ, Pruzinova K, Jancarova M, Volf P, Koenraadt CJM, Duerr HP, Trevitt G, Yang B, Chatterjee AK, Wisler J, Sturm A, Bousema T, Sauerwein RW, Schultz PG, Tremblay MS, Dechering KJ. Miglianico M, et al. Among authors: sturm a. Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6920-E6926. doi: 10.1073/pnas.1801338115. Epub 2018 Jul 2. Proc Natl Acad Sci U S A. 2018. PMID: 29967151 Free PMC article.
Spatial localisation of actin filaments across developmental stages of the malaria parasite.
Angrisano F, Riglar DT, Sturm A, Volz JC, Delves MJ, Zuccala ES, Turnbull L, Dekiwadia C, Olshina MA, Marapana DS, Wong W, Mollard V, Bradin CH, Tonkin CJ, Gunning PW, Ralph SA, Whitchurch CB, Sinden RE, Cowman AF, McFadden GI, Baum J. Angrisano F, et al. Among authors: sturm a. PLoS One. 2012;7(2):e32188. doi: 10.1371/journal.pone.0032188. Epub 2012 Feb 28. PLoS One. 2012. PMID: 22389687 Free PMC article.
Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes.
Goodman CD, Siregar JE, Mollard V, Vega-Rodríguez J, Syafruddin D, Matsuoka H, Matsuzaki M, Toyama T, Sturm A, Cozijnsen A, Jacobs-Lorena M, Kita K, Marzuki S, McFadden GI. Goodman CD, et al. Among authors: sturm a. Science. 2016 Apr 15;352(6283):349-53. doi: 10.1126/science.aad9279. Science. 2016. PMID: 27081071 Free PMC article.
Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast.
Shears MJ, MacRae JI, Mollard V, Goodman CD, Sturm A, Orchard LM, Llinás M, McConville MJ, Botté CY, McFadden GI. Shears MJ, et al. Among authors: sturm a. Cell Microbiol. 2017 Jan;19(1):e12633. doi: 10.1111/cmi.12633. Epub 2016 Aug 1. Cell Microbiol. 2017. PMID: 27324409 Free PMC article.
865 results