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Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts.
Reisinger U, Schwaiger S, Zeller I, Messner B, Stigler R, Wiedemann D, Mayr T, Seger C, Schachner T, Dirsch VM, Vollmar AM, Bonatti JO, Stuppner H, Laufer G, Bernhard D. Reisinger U, et al. Among authors: stuppner h. Cardiovasc Res. 2009 Jun 1;82(3):542-9. doi: 10.1093/cvr/cvp059. Epub 2009 Feb 19. Cardiovasc Res. 2009. PMID: 19228707 Free PMC article.
Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma.
Fakhrudin N, Ladurner A, Atanasov AG, Heiss EH, Baumgartner L, Markt P, Schuster D, Ellmerer EP, Wolber G, Rollinger JM, Stuppner H, Dirsch VM. Fakhrudin N, et al. Among authors: stuppner h. Mol Pharmacol. 2010 Apr;77(4):559-66. doi: 10.1124/mol.109.062141. Epub 2010 Jan 11. Mol Pharmacol. 2010. PMID: 20064974 Free PMC article.
Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques.
Noha SM, Atanasov AG, Schuster D, Markt P, Fakhrudin N, Heiss EH, Schrammel O, Rollinger JM, Stuppner H, Dirsch VM, Wolber G. Noha SM, et al. Among authors: stuppner h. Bioorg Med Chem Lett. 2011 Jan 1;21(1):577-83. doi: 10.1016/j.bmcl.2010.10.051. Epub 2010 Oct 20. Bioorg Med Chem Lett. 2011. PMID: 21078555 Free PMC article.
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.
Baumgartner L, Sosa S, Atanasov AG, Bodensieck A, Fakhrudin N, Bauer J, Favero GD, Ponti C, Heiss EH, Schwaiger S, Ladurner A, Widowitz U, Loggia RD, Rollinger JM, Werz O, Bauer R, Dirsch VM, Tubaro A, Stuppner H. Baumgartner L, et al. Among authors: stuppner h. J Nat Prod. 2011 Aug 26;74(8):1779-86. doi: 10.1021/np200343t. Epub 2011 Jul 29. J Nat Prod. 2011. PMID: 21800856 Free PMC article.
289 results