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The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer.
Adam S, Rossi SE, Moatti N, De Marco Zompit M, Xue Y, Ng TF, Álvarez-Quilón A, Desjardins J, Bhaskaran V, Martino G, Setiaputra D, Noordermeer SM, Ohsumi TK, Hustedt N, Szilard RK, Chaudhary N, Munro M, Veloso A, Melo H, Yin SY, Papp R, Young JTF, Zinda M, Stucki M, Durocher D. Adam S, et al. Among authors: stucki m. Nat Cancer. 2021 Dec;2(12):1357-1371. doi: 10.1038/s43018-021-00266-w. Epub 2021 Nov 11. Nat Cancer. 2021. PMID: 35121901 Free article.
The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis.
De Marco Zompit M, Esteban MT, Mooser C, Adam S, Rossi SE, Jeanrenaud A, Leimbacher PA, Fink D, Shorrocks AK, Blackford AN, Durocher D, Stucki M. De Marco Zompit M, et al. Among authors: stucki m. Nat Commun. 2022 Jul 16;13(1):4143. doi: 10.1038/s41467-022-31865-5. Nat Commun. 2022. PMID: 35842428 Free PMC article.
Mechanisms of genome stability maintenance during cell division.
De Marco Zompit M, Stucki M. De Marco Zompit M, et al. Among authors: stucki m. DNA Repair (Amst). 2021 Dec;108:103215. doi: 10.1016/j.dnarep.2021.103215. Epub 2021 Aug 23. DNA Repair (Amst). 2021. PMID: 34455186 Free article. Review.
MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.
Leimbacher PA, Jones SE, Shorrocks AK, de Marco Zompit M, Day M, Blaauwendraad J, Bundschuh D, Bonham S, Fischer R, Fink D, Kessler BM, Oliver AW, Pearl LH, Blackford AN, Stucki M. Leimbacher PA, et al. Among authors: stucki m. Mol Cell. 2019 May 2;74(3):571-583.e8. doi: 10.1016/j.molcel.2019.02.014. Epub 2019 Mar 18. Mol Cell. 2019. PMID: 30898438 Free PMC article.
Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation.
Mooser C, Symeonidou IE, Leimbacher PA, Ribeiro A, Shorrocks AK, Jungmichel S, Larsen SC, Knechtle K, Jasrotia A, Zurbriggen D, Jeanrenaud A, Leikauf C, Fink D, Nielsen ML, Blackford AN, Stucki M. Mooser C, et al. Among authors: stucki m. Nat Commun. 2020 Jan 8;11(1):123. doi: 10.1038/s41467-019-13981-x. Nat Commun. 2020. PMID: 31913317 Free PMC article.
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells.
Toller IM, Neelsen KJ, Steger M, Hartung ML, Hottiger MO, Stucki M, Kalali B, Gerhard M, Sartori AA, Lopes M, Müller A. Toller IM, et al. Among authors: stucki m. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14944-9. doi: 10.1073/pnas.1100959108. Epub 2011 Sep 6. Proc Natl Acad Sci U S A. 2011. PMID: 21896770 Free PMC article.
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage.
Larsen DH, Hari F, Clapperton JA, Gwerder M, Gutsche K, Altmeyer M, Jungmichel S, Toledo LI, Fink D, Rask MB, Grøfte M, Lukas C, Nielsen ML, Smerdon SJ, Lukas J, Stucki M. Larsen DH, et al. Among authors: stucki m. Nat Cell Biol. 2014 Aug;16(8):792-803. doi: 10.1038/ncb3007. Epub 2014 Jul 27. Nat Cell Biol. 2014. PMID: 25064736 Free PMC article.
MDC1 is required for the intra-S-phase DNA damage checkpoint.
Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, Bartek J, Jackson SP. Goldberg M, et al. Among authors: stucki m. Nature. 2003 Feb 27;421(6926):952-6. doi: 10.1038/nature01445. Nature. 2003. PMID: 12607003
99 results