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Anti-Virulence Therapeutic Approaches for Neisseria gonorrhoeae.
Lim KYL, Mullally CA, Haese EC, Kibble EA, McCluskey NR, Mikucki EC, Thai VC, Stubbs KA, Sarkar-Tyson M, Kahler CM. Lim KYL, et al. Among authors: stubbs ka. Antibiotics (Basel). 2021 Jan 21;10(2):103. doi: 10.3390/antibiotics10020103. Antibiotics (Basel). 2021. PMID: 33494538 Free PMC article. Review.
The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin.
Piek S, Wang Z, Ganguly J, Lakey AM, Bartley SN, Mowlaboccus S, Anandan A, Stubbs KA, Scanlon MJ, Vrielink A, Azadi P, Carlson RW, Kahler CM. Piek S, et al. Among authors: stubbs ka. PLoS One. 2014 Sep 12;9(9):e106513. doi: 10.1371/journal.pone.0106513. eCollection 2014. PLoS One. 2014. PMID: 25215579 Free PMC article.
Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding.
Anandan A, Evans GL, Condic-Jurkic K, O'Mara ML, John CM, Phillips NJ, Jarvis GA, Wills SS, Stubbs KA, Moraes I, Kahler CM, Vrielink A. Anandan A, et al. Among authors: stubbs ka. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2218-2223. doi: 10.1073/pnas.1612927114. Epub 2017 Feb 13. Proc Natl Acad Sci U S A. 2017. PMID: 28193899 Free PMC article.
Enzyme targets for drug design of new anti-virulence therapeutics.
Kahler CM, Sarkar-Tyson M, Kibble EA, Stubbs KA, Vrielink A. Kahler CM, et al. Among authors: stubbs ka. Curr Opin Struct Biol. 2018 Dec;53:140-150. doi: 10.1016/j.sbi.2018.08.010. Epub 2018 Sep 14. Curr Opin Struct Biol. 2018. PMID: 30223251 Free article. Review.
Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase.
Mullally C, Stubbs KA, Thai VC, Anandan A, Bartley S, Scanlon MJ, Jarvis GA, John CM, Lim KYL, Sullivan CM, Sarkar-Tyson M, Vrielink A, Kahler CM. Mullally C, et al. Among authors: stubbs ka. J Antimicrob Chemother. 2022 Aug 25;77(9):2441-2447. doi: 10.1093/jac/dkac204. J Antimicrob Chemother. 2022. PMID: 35770844 Free PMC article.
114 results