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Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2.
Boot RG, Verhoek M, Donker-Koopman W, Strijland A, van Marle J, Overkleeft HS, Wennekes T, Aerts JM. Boot RG, et al. Among authors: strijland a. J Biol Chem. 2007 Jan 12;282(2):1305-12. doi: 10.1074/jbc.M610544200. Epub 2006 Nov 14. J Biol Chem. 2007. PMID: 17105727 Free article.
Elevated globotriaosylsphingosine is a hallmark of Fabry disease.
Aerts JM, Groener JE, Kuiper S, Donker-Koopman WE, Strijland A, Ottenhoff R, van Roomen C, Mirzaian M, Wijburg FA, Linthorst GE, Vedder AC, Rombach SM, Cox-Brinkman J, Somerharju P, Boot RG, Hollak CE, Brady RO, Poorthuis BJ. Aerts JM, et al. Among authors: strijland a. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2812-7. doi: 10.1073/pnas.0712309105. Epub 2008 Feb 19. Proc Natl Acad Sci U S A. 2008. PMID: 18287059 Free PMC article.
Ultrasensitive in situ visualization of active glucocerebrosidase molecules.
Witte MD, Kallemeijn WW, Aten J, Li KY, Strijland A, Donker-Koopman WE, van den Nieuwendijk AM, Bleijlevens B, Kramer G, Florea BI, Hooibrink B, Hollak CE, Ottenhoff R, Boot RG, van der Marel GA, Overkleeft HS, Aerts JM. Witte MD, et al. Among authors: strijland a. Nat Chem Biol. 2010 Dec;6(12):907-13. doi: 10.1038/nchembio.466. Epub 2010 Oct 31. Nat Chem Biol. 2010. PMID: 21079602 Free article.
Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars.
Ghisaidoobe A, Bikker P, de Bruijn AC, Godschalk FD, Rogaar E, Guijt MC, Hagens P, Halma JM, Van't Hart SM, Luitjens SB, van Rixel VH, Wijzenbroek M, Zweegers T, Donker-Koopman WE, Strijland A, Boot R, van der Marel G, Overkleeft HS, Aerts JM, van den Berg RJ. Ghisaidoobe A, et al. Among authors: strijland a. ACS Med Chem Lett. 2010 Dec 2;2(2):119-23. doi: 10.1021/ml100192b. eCollection 2011 Feb 10. ACS Med Chem Lett. 2010. PMID: 24900289 Free PMC article.
46 results